ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. - Wikidata - wikimedia - TriplyDB

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

http://www.wikidata.org/entity/Q30585346

about

Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses ABC50 promotes translation initiation in mammalian cells Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Mcm2 phosphorylation and the response to replicative stress Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1 4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway Genome-wide screen of genes required for caffeine tolerance in fission yeast Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif Cloning and characterization of liver-specific isoform of Chk1 gene from rat p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis Replication protein A (RPA) phosphorylation prevents RPA association with replication centers.Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.A novel protein activity mediates DNA binding of an ATR-ATRIP complex.Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cells Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.Activity of any class IA PI3K isoform can sustain cell proliferation and survival.An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates Preferential binding of ATR protein to UV-damaged DNA.Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.Localisation and regulation of the eIF4E-binding protein 4E-BP3.ATM, a central controller of cellular responses to DNA damage.ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.Is Rad9p upstream or downstream from Mec1p?Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts.

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P2860

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

http://www.wikidata.org/entity/Q30585346

description

1999 nî lūn-bûn

@nan

1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

ATR is a caffeine-sensitive, D ...... cificity distinct from DNA-PK.

@ast

ATR is a caffeine-sensitive, D ...... cificity distinct from DNA-PK.

@en

type

label

ATR is a caffeine-sensitive, D ...... cificity distinct from DNA-PK.

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ATR is a caffeine-sensitive, D ...... cificity distinct from DNA-PK.

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prefLabel

ATR is a caffeine-sensitive, D ...... cificity distinct from DNA-PK.

@ast

ATR is a caffeine-sensitive, D ...... cificity distinct from DNA-PK.

@en

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ATR is a caffeine-sensitive, D ...... cificity distinct from DNA-PK.

@en

P2093

C A Hall-Jackson

http://www.w3.org/2001/XMLSchema#string

C Smythe

http://www.w3.org/2001/XMLSchema#string

D A Cross

http://www.w3.org/2001/XMLSchema#string

N Morrice

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

Lessons from hereditary colorectal cancer

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

P2888

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6707-6713

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scholarly article

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10.1038/SJ.ONC.1203077

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48

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18

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1999-11-01T00:00:00Z

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12704692

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1007194994

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P698

10597277

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