about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationLoading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitroCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Rapid activation of ATR by ionizing radiation requires ATM and Mre11ATR-mediated regulation of nuclear and cellular plasticityThe ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytesHuman claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structuresQuaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activitiesATR: an essential regulator of genome integrityConserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageCyclic nucleotides, the photosynthetic apparatus and response to a UV-B stress in the Cyanobacterium Synechocystis sp. PCC 6803.Many ways to loop DNA.PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysisA novel protein activity mediates DNA binding of an ATR-ATRIP complex.DNA stimulates Mec1-mediated phosphorylation of replication protein A.Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences.Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.BRIT1 regulates early DNA damage response, chromosomal integrity, and cancerFunction of a conserved checkpoint recruitment domain in ATRIP proteins.Identification of the proteomic changes in Synechocystis sp. PCC 6803 following prolonged UV-B irradiation.The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Interplay between Mdm2 and HIPK2 in the DNA damage response.ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice.The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.Requirement of MTA1 in ATR-mediated DNA damage checkpoint function.Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forksAbsence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator AvenTethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)DNA damage and autophagy.Animal models of melanoma: an HGF/SF transgenic mouse model may facilitate experimental access to UV initiating events.Coordination between p21 and DDB2 in the cellular response to UV radiation.Mitogen-activated protein kinase activation in UV-induced signal transduction.UV irradiation induces a postreplication DNA damage checkpoint.Ultraviolet radiation and cutaneous malignant melanoma.Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Preferential binding of ATR protein to UV-damaged DNA.
@ast
Preferential binding of ATR protein to UV-damaged DNA.
@en
Preferential binding of ATR protein to UV-damaged DNA.
@nl
type
label
Preferential binding of ATR protein to UV-damaged DNA.
@ast
Preferential binding of ATR protein to UV-damaged DNA.
@en
Preferential binding of ATR protein to UV-damaged DNA.
@nl
prefLabel
Preferential binding of ATR protein to UV-damaged DNA.
@ast
Preferential binding of ATR protein to UV-damaged DNA.
@en
Preferential binding of ATR protein to UV-damaged DNA.
@nl
P2093
P2860
P356
P1476
Preferential binding of ATR protein to UV-damaged DNA.
@en
P2093
Alexander M Makhov
Jack D Griffith
Keziban Unsal-Kaçmaz
P2860
P304
P356
10.1073/PNAS.102167799
P407
P50
P577
2002-05-01T00:00:00Z