X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
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Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domainIon channels gated by acetylcholine and serotonin: structures, biology, and drug discoveryThe molecular pharmacology of volatile anestheticsPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelGlycine receptor mechanism elucidated by electron cryo-microscopy.Interactions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding ModesCrystal structure of human glycine receptor-α3 bound to antagonist strychnineX-ray structure of the human α4β2 nicotinic receptorEpileptic encephalopathy de novo GABRB mutations impair GABAA receptor functionA Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationSignal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion ChannelsFunctional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor HomologuesEthanol effects on glycinergic transmission: From molecular pharmacology to behavior responsesSeven perspectives on GPCR H/D-exchange proteomics methodsIdentification of a pre-active conformation of a pentameric channel receptorCorrelating structural and energetic changes in glycine receptor activation.Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structureAmiloride and GMQ Allosteric Modulation of the GABA-A ρ1 Receptor: Influences of the Intersubunit Site.Transcriptome Analysis of the Central and Peripheral Nervous Systems of the Spider Cupiennius salei Reveals Multiple Putative Cys-Loop Ligand Gated Ion Channel Subunits and an Acetylcholine Binding Protein.The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptorsFunctional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors.Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α SubunitA Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A ReceptorsRole of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels.Emamectin is a non-selective allosteric activator of nicotinic acetylcholine receptors and GABAA/C receptors.Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytesCrystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamerAllosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazineEngineering differential charge selectivity from a single structural template.A mechanism for acetylcholine receptor gating based on structure, coupling, phi, and flip.Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptorsAltered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome.Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel.The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets.EPR Studies of Gating Mechanisms in Ion Channels.A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation.Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.
P2860
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P2860
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
@ast
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
@en
type
label
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
@ast
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
@en
prefLabel
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
@ast
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
@en
P2860
P356
P1433
P1476
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors
@en
P2093
Eric Gouaux
Ryan E Hibbs
P2860
P2888
P304
P356
10.1038/NATURE13669
P407
P577
2014-08-01T00:00:00Z
P6179
1050241946