Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia.
about
Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeysQuality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?Mitochondrial involvement and impact in aging skeletal muscleMitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trialsRelationship between human aging muscle and oxidative system pathwayMitochondrial dysfunction in cardiac agingMitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator miceMitochondrial biogenesis drives a vicious cycle of metabolic insufficiency and mitochondrial DNA deletion mutation accumulation in aged rat skeletal muscle fibersElevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscleRegulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program.Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection.Mitochondrial DNA deletion mutations and sarcopenia.Stochastic drift in mitochondrial DNA point mutations: a novel perspective ex silicoAddressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.The role of mitochondrial DNA mutations in mammalian agingAccumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber lossAberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adultsCaloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscleAge-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber functionImpact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.Sarcopenia accelerates at advanced ages in Fisher 344xBrown Norway rats.Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'.Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms.Differential regulation of the fiber type-specific gene expression of the sarcoplasmic reticulum calcium-ATPase isoforms induced by exercise training.Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice.Exercise attenuates the major hallmarks of aging.Does calorie restriction induce mitochondrial biogenesis? A reevaluation.Mitochondrial DNA: impacting central and peripheral nervous systems.Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice.Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during agingMitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers.Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance.Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA MutationsProgrammed cell death in aging.The genetics and epigenetics of altered proliferative homeostasis in ageing and cancerSimvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes.Cardiac aging: from molecular mechanisms to significance in human health and diseaseAgeing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production.
P2860
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P2860
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Mitochondrial DNA deletion mut ...... xidative damage in sarcopenia.
@ast
Mitochondrial DNA deletion mut ...... xidative damage in sarcopenia.
@en
type
label
Mitochondrial DNA deletion mut ...... xidative damage in sarcopenia.
@ast
Mitochondrial DNA deletion mut ...... xidative damage in sarcopenia.
@en
prefLabel
Mitochondrial DNA deletion mut ...... xidative damage in sarcopenia.
@ast
Mitochondrial DNA deletion mut ...... xidative damage in sarcopenia.
@en
P2093
P356
P1433
P1476
Mitochondrial DNA deletion mut ...... xidative damage in sarcopenia.
@en
P2093
P304
P356
10.1096/FJ.00-0320COM
P407
P50
P577
2001-02-01T00:00:00Z