Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells.
about
CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and DiseaseA DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cellsNovel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migrationThe SIRP family of receptors and immune regulationCD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interestPositive regulation of phagocytosis by SIRPbeta and its signaling mechanism in macrophagesStructural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interfaceIs the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal?SHPS-1, a multifunctional transmembrane glycoproteinAnti-CD47 Antibody As a Targeted Therapeutic Agent for Human Lung Cancer and Cancer Stem Cells.Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activationMeasurement of macrophage growth and differentiation.The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration.Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.Inhibitory C-type lectin receptors in myeloid cells.CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.Lewis Y antigen modified CD47 is an independent risk factor for poor prognosis and promotes early ovarian cancer metastasisSurfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ)Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice.A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cellsCD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells.Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation.Macrophages as mediators of tumor immunosurveillanceDurable antitumor responses to CD47 blockade require adaptive immune stimulation.SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells.Myeloid Cell Origins, Differentiation, and Clinical Implications.Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's diseaseAnti-SIRPα antibodies as a potential new tool for cancer immunotherapy.The impact of environmental enrichment on the murine inflammatory immune response.CD47: a new player in phagocytosis and xenograft rejection.The innate immune system in transplantation.The CD47-SIRPα signalling system: its physiological roles and therapeutic application.Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling.The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer.Role of the CD47-SHPS-1 system in regulation of cell migrationEvaluation of normal and neoplastic human mast cells for expression of CD172a (SIRPalpha), CD47, and SHP-1.Resistance of B16 melanoma cells to CD47-induced negative regulation of motility as a result of aberrant N-glycosylation of SHPS-1.Ubiquitination-mediated regulation of biosynthesis of the adhesion receptor SHPS-1 in response to endoplasmic reticulum stress.
P2860
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P2860
Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Signal-regulatory protein alph ...... +)CD38(-) hematopoietic cells.
@ast
Signal-regulatory protein alph ...... +)CD38(-) hematopoietic cells.
@en
type
label
Signal-regulatory protein alph ...... +)CD38(-) hematopoietic cells.
@ast
Signal-regulatory protein alph ...... +)CD38(-) hematopoietic cells.
@en
prefLabel
Signal-regulatory protein alph ...... +)CD38(-) hematopoietic cells.
@ast
Signal-regulatory protein alph ...... +)CD38(-) hematopoietic cells.
@en
P2093
P356
P1433
P1476
Signal-regulatory protein alph ...... (+)CD38(-) hematopoietic cells
@en
P2093
H J Bühring
M Seiffert
P Brossart
P304
P356
10.1182/BLOOD.V97.9.2741
P407
P577
2001-05-01T00:00:00Z