about
In silico toxicology: computational methods for the prediction of chemical toxicityMembrane protein structure determination - the next generationPREDICT: a method for inferring novel drug indications with application to personalized medicineA Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane MetallopeptidasesPrioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosisLipid-protein interactions of integral membrane proteins: a comparative simulation study.Improvement of the treatment of loop structures in the UNRES force field by inclusion of coupling between backbone- and side-chain-local conformational states.Computational analysis of membrane proteins: the largest class of drug targets.Comprehensive structural and functional characterization of the human kinome by protein structure modeling and ligand virtual screening.Automated parallel recordings of topologically identified single ion channelsConformation and environment of channel-forming peptides: a simulation studyAutomated builder and database of protein/membrane complexes for molecular dynamics simulations.Signal transduction profiling using label-free biosensors.The application of the Escherichia coli giant spheroplast for drug screening with automated planar patch clamp systemChanges in transmembrane helix alignment by arginine residues revealed by solid-state NMR experiments and coarse-grained MD simulations.Genome-wide metabolic (re-) annotation of Kluyveromyces lactis.The use of selective adsorbents in capillary electrophoresis-mass spectrometry for analyte preconcentration and microreactions: a powerful three-dimensional tool for multiple chemical and biological applications.New in silico and conventional in vitro approaches to advance HIV drug discovery and design.Membrane insertion of a voltage sensor helixBinding modes of peptidomimetics designed to inhibit STAT3.Physics-based potentials for the coupling between backbone- and side-chain-local conformational states in the UNited RESidue (UNRES) force field for protein simulations.Prediction of multi-type membrane proteins in human by an integrated approach.Amino-acid solvation structure in transmembrane helices from molecular dynamics simulations.The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor.The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C.Quantitative analysis on the characteristics of targets with FDA approved drugs.Using grid techniques for drug target identification.Using EGFP fusions to monitor the functional expression of GPCRs in the Drosophila Schneider 2 cells.Ligand binding site identification by higher dimension molecular dynamicsSAHBNET, an accessible surface-based elastic network: an application to membrane protein.Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies.Potential benefits of Chinese Herbal Medicine for elderly patients with cardiovascular diseases.Using genetic findings in autism for the development of new pharmaceutical compounds.Challenges in structural approaches to cell modeling.Solving Immunology?Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs.Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry.Exploring peptide-membrane interactions with coarse-grained MD simulations.Improving structural similarity based virtual screening using background knowledge.A generalized born implicit-membrane representation compared to experimental insertion free energies.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
In silico research in drug discovery.
@ast
In silico research in drug discovery.
@en
type
label
In silico research in drug discovery.
@ast
In silico research in drug discovery.
@en
prefLabel
In silico research in drug discovery.
@ast
In silico research in drug discovery.
@en
P1476
In silico research in drug discovery.
@en
P2093
Reggiani A
Terstappen GC
P356
10.1016/S0165-6147(00)01584-4
P577
2001-01-01T00:00:00Z