Molecular architecture and mechanism of the anaphase-promoting complex
about
Insights into APC/C: from cellular function to diseases and therapeuticsUbiquitin-Mediated Degradation of Aurora KinasesDual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1Quantitative framework for ordered degradation of APC/C substrates.Atomic structure of the APC/C and its mechanism of protein ubiquitination.Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry.Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationAPC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathwayA decade of the anaphase-promoting complex in the nervous systemSpatiotemporal regulation of the anaphase-promoting complex in mitosisCrystal Structure of a Ube2S-Ubiquitin ConjugateDonkey genome and insight into the imprinting of fast karyotype evolutionPlasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in MosquitoesMolecular mechanism of APC/C activation by mitotic phosphorylation.Molecular basis of APC/C regulation by the spindle assembly checkpoint.Activation of the APC/C ubiquitin ligase by enhanced E2 efficiencyInitiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometryThe biochemistry of mitosisMASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.Single-Particle Cryo-EM at Crystallographic ResolutionRING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complexTargeting Cdc20 as a novel cancer therapeutic strategy.TDM1 Regulation Determines the Number of Meiotic Divisions.MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkagesCdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.Dual functionality of O-GlcNAc transferase is required for Drosophila development.Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylationA strategy for dissecting the architectures of native macromolecular assembliesThe Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans.Mechanism of APC/CCDC20 activation by mitotic phosphorylation.Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated ProteolysisWD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.Human cytomegalovirus riding the cell cycle.Measuring APC/C-Dependent Ubiquitylation In Vitro.The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis.Specificity and disease in the ubiquitin system
P2860
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P2860
Molecular architecture and mechanism of the anaphase-promoting complex
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Molecular architecture and mechanism of the anaphase-promoting complex
@ast
Molecular architecture and mechanism of the anaphase-promoting complex
@en
type
label
Molecular architecture and mechanism of the anaphase-promoting complex
@ast
Molecular architecture and mechanism of the anaphase-promoting complex
@en
prefLabel
Molecular architecture and mechanism of the anaphase-promoting complex
@ast
Molecular architecture and mechanism of the anaphase-promoting complex
@en
P2860
P50
P356
P1433
P1476
Molecular architecture and mechanism of the anaphase-promoting complex
@en
P2093
David Barford
Lei-Fu Chang
P2860
P2888
P304
P356
10.1038/NATURE13543
P407
P577
2014-07-20T00:00:00Z