FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
about
Amyloid-β Receptors: The Good, the Bad, and the Prion ProteinAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficitsAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicityMicroglia as a critical player in both developmental and late-life CNS pathologies.The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.Alzheimer's protective A2T mutation changes the conformational landscape of the Aβ₁₋₄₂ monomer differently than does the A2V mutation.IgG Conformer's Binding to Amyloidogenic Aggregates.Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity.Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis.APP Receptor? To Be or Not To Be.Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis.Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's Disease.The Binding Receptors of Aβ: an Alternative Therapeutic Target for Alzheimer's Disease.Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?Actin dynamics and cofilin-actin rods in alzheimer disease.Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity.Role of amyloid β protein receptors in mediating synaptic plasticity.Amyloid beta: structure, biology and structure-based therapeutic development.Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the BrainIdentification of approved drugs that inhibit the binding of amyloid β oligomers to ephrin type-B receptor 2.Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury.Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses.Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay.Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner.Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex.A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition.Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5.The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer's Disease
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P2860
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
@ast
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
@en
type
label
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
@ast
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
@en
prefLabel
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
@ast
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
@en
P2093
P2860
P50
P921
P356
P1476
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
@en
P2093
Dong-Keun Song
Hyejin Park
Jeongyeon Kim
Ji-Jing Yan
Ji-Woo Choi
Junying Yuan
Key-Sun Kim
Sukwoo Choi
Sungmin Song
P2860
P304
P356
10.1172/JCI66827
P407
P577
2013-06-10T00:00:00Z