Alzheimer's protective A2T mutation changes the conformational landscape of the Aβ₁₋₄₂ monomer differently than does the A2V mutation.

Alzheimer's protective A2T mutation changes the conformational landscape of the Aβ₁₋₄₂ monomer differently than does the A2V mutation.

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http://www.wikidata.org/entity/Q35050571
Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation.Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity.Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation.Amylin-Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's diseaseAllosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal.Exploring the aggregation free energy landscape of the amyloid-β protein (1-40).High-Resolution Structures of the Amyloid-β 1-42 Dimers from the Comparison of Four Atomistic Force Fields.Comparison of force fields for Alzheimer's A β42: A case study for intrinsically disordered proteins.Emergence of Alternative Structures in Amyloid Beta 1-42 Monomeric Landscape by N-terminal Hexapeptide Amyloid Inhibitors.Conformational Ensembles of the Wild-Type and S8C Aβ1-42 Dimers.Molecular dynamics simulations and novel drug discovery.Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition.Looking at the Disordered Proteins through the Computational Microscope.
P2860

Alzheimer's protective A2T mutation changes the conformational landscape of the Aβ₁₋₄₂ monomer differently than does the A2V mutation.

Item
http://www.wikidata.org/entity/Q35050571
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2015 nî lūn-bûn
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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2015 թվականի փետրվարին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
@zh-mo
2015年論文
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2015年论文
@wuu
name
Alzheimer's protective A2T mut ...... ly than does the A2V mutation.
@ast
Alzheimer's protective A2T mut ...... ly than does the A2V mutation.
@en
type
label
Alzheimer's protective A2T mut ...... ly than does the A2V mutation.
@ast
Alzheimer's protective A2T mut ...... ly than does the A2V mutation.
@en
prefLabel
Alzheimer's protective A2T mut ...... ly than does the A2V mutation.
@ast
Alzheimer's protective A2T mut ...... ly than does the A2V mutation.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Alzheimer's protective A2T mut ...... ly than does the A2V mutation.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932