Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses
about
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injuryMolecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoformDeletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesisPDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilastPDE4 as a target for cognition enhancementA phosphodiesterase 4B-dependent interplay between tumor cells and the microenvironment regulates angiogenesis in B-cell lymphoma.Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitorsStructural basis for the design of selective phosphodiesterase 4B inhibitorsSelective Phosphodiesterase 4B Inhibitors: A ReviewSuppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphologyMice deficient in phosphodiesterase-4A display anxiogenic-like behaviorCarbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal TLR4 to NF-kappaB signal transduction in human monocytesA family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn ratsPhosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytesAging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways.Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.Effects of inactivated Bordetella pertussis on phosphodiesterase in the lung of ovalbumin sensitized and challenged rats.Sudachitin, a polymethoxyflavone from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells.Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitorAdvances in targeting cyclic nucleotide phosphodiesterasesGram-positive pathogenic bacteria induce a common early response in human monocytesPhosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthmaThe effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthmaDistinct roles of adenylyl cyclase VII in regulating the immune responses in micePDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblastsCyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway.ABCD of the phosphodiesterase family: interaction and differential activity in COPDPDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationThe upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseInhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells.Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury.Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.The PDE4 inhibitor rolipram prevents NF-kappaB binding activity and proinflammatory cytokine release in human chorionic cellsThe unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.
P2860
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P2860
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Induction of the cyclic nucleo ...... -activated TNF-alpha responses
@ast
Induction of the cyclic nucleo ...... -activated TNF-alpha responses
@en
type
label
Induction of the cyclic nucleo ...... -activated TNF-alpha responses
@ast
Induction of the cyclic nucleo ...... -activated TNF-alpha responses
@en
prefLabel
Induction of the cyclic nucleo ...... -activated TNF-alpha responses
@ast
Induction of the cyclic nucleo ...... -activated TNF-alpha responses
@en
P2860
P356
P1476
Induction of the cyclic nucleo ...... -activated TNF-alpha responses
@en
P2093
Marco Conti
S-L Catherine Jin
P2860
P304
P356
10.1073/PNAS.122041599
P407
P577
2002-05-01T00:00:00Z