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An array of target-specific screening strains for antibacterial discovery.

An array of target-specific screening strains for antibacterial discovery.

http://www.wikidata.org/entity/Q30834642

about

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor Breaking the Spell: Combating Multidrug Resistant 'Superbugs'The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques New insights into TB physiology suggest untapped therapeutic opportunities An IPTG Inducible Conditional Expression System for Mycobacteria Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.Conserved fungal genes as potential targets for broad-spectrum antifungal drug discovery.Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: generating an antibiotic bar code.Challenges of antibacterial discovery Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening Cysteinyl-tRNA(Cys) formation in Methanocaldococcus jannaschii: the mechanism is still unknown.Burkholderia cenocepacia conditional growth mutant library created by random promoter replacement of essential genes.Reverse engineering gene networks: integrating genetic perturbations with dynamical modeling.Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli Antifungal and cytotoxicity activities of the fresh xylem sap of Hymenaea courbaril L. and its major constituent fisetin.Tunable protein degradation in bacteria.Genetic Approaches to Facilitate Antibacterial Drug Development.Seeing is believing: the impact of structural genomics on antimicrobial drug discovery.Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents.Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli Cytoplasmic steps of peptidoglycan biosynthesis.Screening strategies for discovery of antibacterial natural products.Overview of anti-infective drug development.Overview of antibacterial target selection.Genomic tools to profile antibiotic mode of action.An array of Escherichia coli clones over-expressing essential proteins: a new strategy of identifying cellular targets of potent antibacterial compounds.Strategies for target identification of antimicrobial natural products.An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs.Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants.Identification of antibiotic stress-inducible promoters: a systematic approach to novel pathway-specific reporter assays for antibacterial drug discovery.Conditional lethal amber mutations in essential Escherichia coli genes Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.Target-based whole-cell screening by ¹H NMR spectroscopy A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds.Recombineering with tolC as a selectable/counter-selectable marker: remodeling the rRNA operons of Escherichia coli.

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P2860

An array of target-specific screening strains for antibacterial discovery.

http://www.wikidata.org/entity/Q30834642

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

An array of target-specific screening strains for antibacterial discovery.

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An array of target-specific screening strains for antibacterial discovery.

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An array of target-specific screening strains for antibacterial discovery.

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An array of target-specific screening strains for antibacterial discovery.

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prefLabel

An array of target-specific screening strains for antibacterial discovery.

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An array of target-specific screening strains for antibacterial discovery.

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Nature Biotechnology

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An array of target-specific screening strains for antibacterial discovery.

@en

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Anjana Agarwal

http://www.w3.org/2001/XMLSchema#string

Christine F Sizemore

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Daniel M Stoughton

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David L Pompliano

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Jonathan A Mills

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Joseph A DeVito

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Lorie A Foster

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Maria D F S Barbosa

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Maria Grazia Cappiello

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Veronica G Liu

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P2860

Lateral gene transfer and the nature of bacterial innovation

Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

An efficient recombination system for chromosome engineering in Escherichia coli

A new logic for DNA engineering using recombination in Escherichia coli

Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.

Regulation of the L-arabinose operon of Escherichia coli.

Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu

Antimicrobial use and bacterial resistance.

Finding drug targets in microbial genomes.

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478-483

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10.1038/NBT0502-478

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5

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20

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2002-05-01T00:00:00Z

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11981561

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