Efficient isolation of soluble intracellular single-chain antibodies using the twin-arginine translocation machinery.
about
Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?Specific in vivo knockdown of protein function by intrabodiesA microbial sensor for discovering structural probes of protein misfolding and aggregationDirected Evolution of Human Heavy Chain Variable Domain (VH) Using In Vivo Protein Fitness FilterIn-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulationStrategies for successful recombinant expression of disulfide bond-dependent proteins in Escherichia coli.Analysis of the relationship between end-to-end distance and activity of single-chain antibody against colorectal carcinoma.Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm.Visualizing interactions along the Escherichia coli twin-arginine translocation pathway using protein fragment complementation.Engineering antibody fitness and function using membrane-anchored display of correctly folded proteins.Optimizing recombinant antibodies for intracellular function using hitchhiker-mediated survival selectionStrain engineering for improved expression of recombinant proteins in bacteriaGrowth signalobody selects functional intrabodies in the mammalian cytoplasm.An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal ModelTargeting antibodies to the cytoplasm.Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.A rapid protein folding assay for the bacterial periplasm.Repurposing a bacterial quality control mechanism to enhance enzyme production in living cellsThe ribosomal exit tunnel as a target for optimizing protein expression in Escherichia coli.Mining mammalian genomes for folding competent proteins using Tat-dependent genetic selection in Escherichia coli.Bioinformatics-led design of single-chain antibody molecules targeting DNA sequences for retinoblastoma.Optimizing heterologous protein production in the periplasm of E. coli by regulating gene expression levels.Directed evolution to improve protein folding in vivo.
P2860
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P2860
Efficient isolation of soluble intracellular single-chain antibodies using the twin-arginine translocation machinery.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Efficient isolation of soluble ...... inine translocation machinery.
@ast
Efficient isolation of soluble ...... inine translocation machinery.
@en
type
label
Efficient isolation of soluble ...... inine translocation machinery.
@ast
Efficient isolation of soluble ...... inine translocation machinery.
@en
prefLabel
Efficient isolation of soluble ...... inine translocation machinery.
@ast
Efficient isolation of soluble ...... inine translocation machinery.
@en
P2860
P1476
Efficient isolation of soluble ...... inine translocation machinery.
@en
P2093
Adam C Fisher
P2860
P304
P356
10.1016/J.JMB.2008.10.051
P407
P577
2008-11-01T00:00:00Z