Two tarantula peptides inhibit activation of multiple sodium channels.
about
Crystallographic insights into sodium-channel modulation by the β4 subunitSolution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channelsInteractions between lipids and voltage sensor paddles detected with tarantula toxinsThe hitchhiker's guide to the voltage-gated sodium channel galaxyPeptide neurotoxins that affect voltage-gated calcium channels: a close-up on ω-agatoxinsFrom foe to friend: using animal toxins to investigate ion channel functionAnalysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating DomainIsolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs.Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Targeting voltage sensors in sodium channels with spider toxins.Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.Molecular Cloning and Sequence Analysis of the cDNAs Encoding Toxin-Like Peptides from the Venom Glands of Tarantula Grammostola rosea.Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes.The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cellsThe poison Dart frog's batrachotoxin modulates Nav1.8.Voltage-gated sodium channel modulation by scorpion alpha-toxins.Tarantula toxins interacting with voltage sensors in potassium channels.Spider peptide toxins as leads for drug development.The roles of sodium channels in nociception: Implications for mechanisms of painProduction of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.Structural interactions of a voltage sensor toxin with lipid membranes.Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and MygalomorphaeComputational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics.Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensorsSpider-venom peptides as therapeutics.Palmitoylation influences the function and pharmacology of sodium channels.Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.Temporal dynamics of anxiety phenotypes in a dental pulp injury modelBioinformatics-Aided VenomicsXenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.Centipede venoms as a source of drug leads.Animal toxins can alter the function of Nav1.8 and Nav1.9.Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels
P2860
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P2860
Two tarantula peptides inhibit activation of multiple sodium channels.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Two tarantula peptides inhibit activation of multiple sodium channels.
@ast
Two tarantula peptides inhibit activation of multiple sodium channels.
@en
type
label
Two tarantula peptides inhibit activation of multiple sodium channels.
@ast
Two tarantula peptides inhibit activation of multiple sodium channels.
@en
prefLabel
Two tarantula peptides inhibit activation of multiple sodium channels.
@ast
Two tarantula peptides inhibit activation of multiple sodium channels.
@en
P2093
P356
P1433
P1476
Two tarantula peptides inhibit activation of multiple sodium channels.
@en
P2093
Charles J Cohen
Chou J Liu
Jeremy C Hwang
John T Mehl
Martin G Kohler
McHardy M Smith
Michael J Bogusky
Richard E Middleton
Richard L Kraus
P304
14734-14747
P356
10.1021/BI026546A
P407
P577
2002-12-01T00:00:00Z