Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. - Wikidata - wikimedia - TriplyDB

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

http://www.wikidata.org/entity/Q30881593

about

THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space.Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death : Omi/HtrA2 and aged heart injury HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA)Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: role of AMP-activated protein kinase.Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration.Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death.Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model.Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells.Mitochondrial effectors in caspase-independent cell death.The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2 Caspase-dependent and -independent neuronal death: two distinct pathways to neuronal injury.UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK.The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C.Apoptosis regulation at the mitochondrial outer membrane.Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.Effect of MCM09, an active site-directed inhibitor of factor Xa, on B16-BL6 melanoma lung colonies in mice.Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP.The salt-sensitive structure and zinc inhibition of Borrelia burgdorferi protease BbHtrA.Protection Against Cold Storage-Induced Renal Tubular Cell Apoptosis.Type I interferons activate apoptosis in a Jurkat cell variant by caspase-dependent and independent mechanisms The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis.Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.Acute renal failure in zebrafish: a novel system to study a complex disease.Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2.Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis.TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation.XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway.Protective Effects of UCF-101 on Cerebral Ischemia-Reperfusion (CIR) is Depended on the MAPK/p38/ERK Signaling Pathway.The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines

P2860

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P2860

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

http://www.wikidata.org/entity/Q30881593

description

2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Characterization of a novel an ...... -apoptotic protease Omi/HtrA2.

@ast

Characterization of a novel an ...... -apoptotic protease Omi/HtrA2.

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type

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Characterization of a novel an ...... -apoptotic protease Omi/HtrA2.

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Characterization of a novel an ...... -apoptotic protease Omi/HtrA2.

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prefLabel

Characterization of a novel an ...... -apoptotic protease Omi/HtrA2.

@ast

Characterization of a novel an ...... -apoptotic protease Omi/HtrA2.

@en

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P1433

Journal of Biological Chemistry

P1476

Characterization of a novel an ...... -apoptotic protease Omi/HtrA2.

@en

P2093

Antonis S Zervos

http://www.w3.org/2001/XMLSchema#string

Daniela Junqueira

http://www.w3.org/2001/XMLSchema#string

Emad S Alnemri

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Hedvika Davis

http://www.w3.org/2001/XMLSchema#string

Joseph V Bonventre

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Kwon Moo Park

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Lucia Cilenti

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Sibylle Hess

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Srinivasa Srinivasula

http://www.w3.org/2001/XMLSchema#string

Younghee Lee

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P2860

Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage

Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

An alternative, nonapoptotic form of programmed cell death

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

P304

11489-11494

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scholarly article

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10.1074/JBC.M212819200

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P433

13

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P478

278

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2003-01-15T00:00:00Z

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12529364

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P921

apoptotic process