Formation of 13C-, 15N-, and 18O-labeled guanidinohydantoin from guanosine oxidation with singlet oxygen. Implications for structure and mechanism.
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Crystal Structure of a Replicative DNA Polymerase Bound to the Oxidized Guanine Lesion Guanidinohydantoin ,Toxoflavin Lyase Requires a Novel 1-His-2-Carboxylate Facial Triad,Surviving an Oxygen Atmosphere: DNA Damage and RepairReconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.Characterization of 2'-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contextsBiological properties of single chemical-DNA adducts: a twenty year perspectiveMechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions.Guanine-specific oxidation of double-stranded DNA by Cr(VI) and ascorbic acid forms spiroiminodihydantoin and 8-oxo-2'-deoxyguanosine.Nei deficient Escherichia coli are sensitive to chromate and accumulate the oxidized guanine lesion spiroiminodihydantoin.DNA interstrand cross-link formation initiated by reaction between singlet oxygen and a modified nucleotideComparison of Transition Metal-Mediated Oxidation Reactions of Guanine in Nucleoside and Single-Stranded Oligodeoxynucleotide Contexts.Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts.5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA ContextsBase and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA.Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation.Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore.Thermodynamic consequences of the hyperoxidized guanine lesion guanidinohydantoin in duplex DNAComparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen, and γ-radiationElucidating DNA damage and repair processes by independently generating reactive and metastable intermediates.pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion.In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase.Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli FpgSuperior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems.Structural destabilization of DNA duplexes containing single-base lesions investigated by nanopore measurementsEndonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.DNA damage spectra induced by photosensitization.Chemical and biological consequences of oxidatively damaged guanine in DNA.Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers.The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.Formation and processing of DNA damage substrates for the hNEIL enzymes.Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products.Formation and repair of oxidatively generated damage in cellular DNA.8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis.Synthesis and characterization of the oxidized dGTP lesions spiroiminodihydantoin-2'-deoxynucleoside-5'- triphosphate and guanidinohydantoin-2'-deoxynucleoside-5'- triphosphate.Capturing Transient Endoperoxide in the Singlet Oxygen Oxidation of Guanine.The R- and S-diastereoisomeric effects on the guanidinohydantoin-induced mutations in DNA.G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.
P2860
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P2860
Formation of 13C-, 15N-, and 18O-labeled guanidinohydantoin from guanosine oxidation with singlet oxygen. Implications for structure and mechanism.
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Formation of 13C-, 15N-, and 1 ...... s for structure and mechanism.
@ast
Formation of 13C-, 15N-, and 1 ...... s for structure and mechanism.
@en
type
label
Formation of 13C-, 15N-, and 1 ...... s for structure and mechanism.
@ast
Formation of 13C-, 15N-, and 1 ...... s for structure and mechanism.
@en
prefLabel
Formation of 13C-, 15N-, and 1 ...... s for structure and mechanism.
@ast
Formation of 13C-, 15N-, and 1 ...... s for structure and mechanism.
@en
P2093
P356
P1476
Formation of 13C-, 15N-, and 1 ...... s for structure and mechanism.
@en
P2093
Anthony J Shallop
Charles L Mayne
Cynthia J Burrows
James G Muller
Roger A Jones
Wenchen Luo
P304
13926-13927
P356
10.1021/JA0378660
P407
P577
2003-11-01T00:00:00Z