Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. - Wikidata - wikimedia - TriplyDB

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

http://www.wikidata.org/entity/Q30912415

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SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies Components of cancer metabolism and therapeutic interventions The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity From sirtuin biology to human diseases: an update Sirtuin deacylases: a molecular link between metabolism and immunity Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis.Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.NAD+ protects against EAE by regulating CD4+ T-cell differentiation EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity Adipocytokine profile, cytokine levels and foxp3 expression in multiple sclerosis: a possible link to susceptibility and clinical course of disease.Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells.NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.Intracellular NAD⁺ depletion enhances bortezomib-induced anti-myeloma activity.CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866.PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis?Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity.Physiological and pathophysiological roles of NAMPT and NAD metabolism.Sirt6 regulates dendritic cell differentiation, maturation, and function.Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis.Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody.Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin.Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity.NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children.Secondary NAD+ deficiency in the inherited defect of glutamine synthetase.

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P2860

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

http://www.wikidata.org/entity/Q30912415

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2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

A new mathematical model for relative quantification in real-time RT-PCR

Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors

Cell death: critical control points

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

NAD kinase levels control the NADPH concentration in human cells

A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

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