A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.
about
Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactoneEnzymatic methods for glyco(diversification/randomization) of drugs and small moleculesThe in vitro characterization of polyene glycosyltransferases AmphDI and NysDICrosstalk between ROS homeostasis and secondary metabolism in S. natalensis ATCC 27448: modulation of pimaricin production by intracellular ROSSelvamicin, an atypical antifungal polyene from two alternative genomic contextsCholesterol oxidase: physiological functions.Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibioticPropanol addition improves natamycin biosynthesis of Streptomyces natalensis.CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces.Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity.Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes.Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects.Polyene antibiotic biosynthesis gene clusters.The enzymology of combinatorial biosynthesis.A multienzyme complex channels substrates and electrons through acetyl-CoA and methane biosynthesis pathways in Methanosarcina.Gamma-butyrolactone regulatory system of Streptomyces chattanoogensis links nutrient utilization, metabolism, and development.Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story.Efflux-mediated antimicrobial resistance.Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes.Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones.Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.Comparative Genomic and Regulatory Analyses of Natamycin Production of Streptomyces lydicus A02.Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae.Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.The efflux pump inhibitor reserpine selects multidrug-resistant Streptococcus pneumoniae strains that overexpress the ABC transporters PatA and PatB.Genome mining of the biosynthetic gene cluster of the polyene macrolide antibiotic tetramycin and characterization of a P450 monooxygenase involved in the hydroxylation of the tetramycin B polyol segment.Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei.SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02.Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.Characterization of type II thioesterases involved in natamycin biosynthesis in Streptomyces chattanoogensis L10.Mutational analysis of a type II thioesterase associated with nonribosomal peptide synthesis.Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns.
P2860
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P2860
A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
A complex multienzyme system e ...... in in Streptomyces natalensis.
@ast
A complex multienzyme system e ...... in in Streptomyces natalensis.
@en
type
label
A complex multienzyme system e ...... in in Streptomyces natalensis.
@ast
A complex multienzyme system e ...... in in Streptomyces natalensis.
@en
prefLabel
A complex multienzyme system e ...... in in Streptomyces natalensis.
@ast
A complex multienzyme system e ...... in in Streptomyces natalensis.
@en
P2093
P1476
A complex multienzyme system e ...... in in Streptomyces natalensis.
@en
P2093
P304
P356
10.1016/S1074-5521(00)00038-7
P577
2000-11-01T00:00:00Z