Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
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alpha-Synuclein and neuronal cell deathParkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitroLRRK2 phosphorylates novel tau epitopes and promotes tauopathyCerebrospinal Fluid Amyloid β1-42, Tau, and Alpha-Synuclein Predict the Heterogeneous Progression of Cognitive Dysfunction in Parkinson's DiseaseThe genetics and neuropathology of Parkinson's diseaseNeuropathology in mice expressing mouse alpha-synucleinParkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.Alpha-synuclein and tau: teammates in neurodegeneration?Distinct α-synuclein strains differentially promote tau inclusions in neuronsExploring the Effects of Genetic Variants on Clinical Profiles of Parkinson's Disease Assessed by the Unified Parkinson's Disease Rating Scale and the Hoehn-Yahr StageAn Alzheimer's Disease-Derived Biomarker Signature Identifies Parkinson's Disease Patients with Dementiaα-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.Evaluation of alpha-synuclein immunohistochemical methods used by invited expertsNeuropathologic substrates of Parkinson disease dementia.Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelBiomarker identification in neurologic diseases: improving diagnostics and therapeutics.Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behaviorThe PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's diseaseTau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementiaTau reduction does not prevent motor deficits in two mouse models of Parkinson's diseaseAlpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.Prion strain interactions are highly selective.Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins.Familial occurrence of dementia with Lewy bodies.Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.Genetic neuropathology of Parkinson's disease.Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.Genotype-phenotype correlation: familial Parkinson disease.Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse modelMechanism of neurodegenerative disease: role of the ubiquitin proteasome system.Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Parkinson's disease: the genetics of a heterogeneous disorder.Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathiesAn evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease.
P2860
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P2860
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
@ast
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
@en
type
label
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
@ast
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
@en
prefLabel
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
@ast
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
@en
P2093
P1476
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
@en
P2093
Benoit I Giasson
Douglas C Miller
John E Duda
Lawrence I Golbe
Meghann E Mabon
Virginia M-Y Lee
P2888
P356
10.1007/S00401-002-0563-3
P577
2002-04-27T00:00:00Z
P6179
1022431004