α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
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The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicityPropagation of prions causing synucleinopathies in cultured cellsDefinition of a molecular pathway mediating α-synuclein neurotoxicityα-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationEvaluation of Models of Parkinson's DiseaseΑlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's DiseaseGenetics Underlying Atypical Parkinsonism and Related Neurodegenerative DisordersEvidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonismTargeting heat shock proteins to modulate α-synuclein toxicityAdult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticityPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cellsAlpha-synuclein and tau: teammates in neurodegeneration?Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug ScreeningNovel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease.The Monoamine Brainstem Reticular Formation as a Paradigm for Re-Defining Various Phenotypes of Parkinson's Disease Owing Genetic and Anatomical Specificity.Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degenerationα-Synuclein mutations cluster around a putative protein loop.Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease.Towards translational therapies for multiple system atrophyα-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP productionThe novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicityMultiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathiesAnalysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.The genetic background of Parkinson's disease: current progress and future prospects.Alpha-synuclein mRNA expression in oligodendrocytes in MSA.Analysis of C9orf72 repeat expansions in a large series of clinically and pathologically diagnosed cases with atypical parkinsonism.Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivoSystematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.Variants associated with Gaucher disease in multiple system atrophy.Association of the COQ2 V393A Variant with Parkinson's Disease: A Case-Control Study and Meta-AnalysisEffects of impaired membrane interactions on α-synuclein aggregation and neurotoxicityPlasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study.The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell cultureParkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
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P2860
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
α-Synucleinopathy associated w ...... e and multiple system atrophy?
@en
type
label
α-Synucleinopathy associated w ...... e and multiple system atrophy?
@en
prefLabel
α-Synucleinopathy associated w ...... e and multiple system atrophy?
@en
P2093
P2860
P50
P1476
α-Synucleinopathy associated w ...... e and multiple system atrophy?
@en
P2093
Aoife P Kiely
Christos Proukakis
Eleanna Kara
Helen Ling
Henry Houlden
Janice L Holton
Patrick Lewis
Tamas Revesz
Yasmine T Asi
P2860
P2888
P304
P356
10.1007/S00401-013-1096-7
P577
2013-02-12T00:00:00Z