HIPK2: a multitalented partner for transcription factors in DNA damage response and development.
about
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsHomeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiationHow cells switch HIPK2 on and offThe human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosisQuantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targetsCofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1.Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex.Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survivalHIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas.High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradationMUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathwayHIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.CtBP2 downregulation during neural crest specification induces expression of Mitf and REST, resulting in melanocyte differentiation and sympathoadrenal lineage suppression.Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activityHIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicityUpdates on HIPK2: a resourceful oncosuppressor for clearing cancerGenetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans.Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapyPARP1 regulates the protein stability and proapoptotic function of HIPK2.Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.Wnt signaling through T-cell factor phosphorylation.Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.HIPK2 modification code for cell death and survival.miR-141 regulates TGF-β1-induced epithelial-mesenchymal transition through repression of HIPK2 expression in renal tubular epithelial cells.Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage.A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cellsHomeodomain-interacting protein kinase2 in human idiopathic pulmonary fibrosis.HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300.Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2.Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).
P2860
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P2860
HIPK2: a multitalented partner for transcription factors in DNA damage response and development.
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
HIPK2: a multitalented partner ...... mage response and development.
@ast
HIPK2: a multitalented partner ...... mage response and development.
@en
type
label
HIPK2: a multitalented partner ...... mage response and development.
@ast
HIPK2: a multitalented partner ...... mage response and development.
@en
prefLabel
HIPK2: a multitalented partner ...... mage response and development.
@ast
HIPK2: a multitalented partner ...... mage response and development.
@en
P2860
P356
P1476
HIPK2: a multitalented partner ...... amage response and development
@en
P2093
Andrea Prodosmo
Francesca Siepi
P2860
P304
P356
10.1139/O07-071
P577
2007-08-01T00:00:00Z