HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity
about
Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replicationHeterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells.Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression.Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities.HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.
P2860
Q36485117-E20A2191-5336-4BBB-A7C8-1390CC4BF4C9Q36738933-3E145F0A-9FBE-4ACB-8DCD-ADDF0BA2AE23Q36781670-88B2C250-8233-4514-83B9-F8E40727AD5FQ37725499-D8ACFC7A-8CDA-46EF-8D26-72BF7DBF0395Q37746347-C4511BA8-1743-45B0-AD7B-4FD179628A97Q38801439-84AFE185-ABAA-42AA-9A32-DD980A9DBED8Q40653190-BCFD4CE9-7BA9-4947-9AD5-6ADC388EC0C2Q52725117-8599E710-421B-4492-94E3-C7D7657AC4EF
P2860
HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity
description
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name
HIPK2 deficiency causes chromo ...... e and increases tumorigenicity
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HIPK2 deficiency causes chromo ...... e and increases tumorigenicity
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type
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HIPK2 deficiency causes chromo ...... e and increases tumorigenicity
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HIPK2 deficiency causes chromo ...... e and increases tumorigenicity
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HIPK2 deficiency causes chromo ...... e and increases tumorigenicity
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HIPK2 deficiency causes chromo ...... e and increases tumorigenicity
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P2093
P2860
P50
P356
P1433
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HIPK2 deficiency causes chromo ...... e and increases tumorigenicity
@en
P2093
Alfredo Fusco
Alice Moncada
Davide Valente
Eva Diamantis Karamitopoulou
Gianluca Bossi
Giovanna Maria Pierantoni
Mara Tornincasa
Stefania Indelicato
P2860
P304
10320-10334
P356
10.18632/ONCOTARGET.3583
P407
P577
2015-04-01T00:00:00Z