Potent inhibition of scrapie prion replication in cultured cells by bis-acridines. - Wikidata - wikimedia - TriplyDB

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

http://www.wikidata.org/entity/Q31134598

about

Continuous quinacrine treatment results in the formation of drug-resistant prions 2-Aminothiazoles as therapeutic leads for prion diseases Hot spots in prion protein for pathogenic conversion Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.Chemical induction of misfolded prion protein conformers in cell culture.The concept of privileged structures in rational drug design: focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases.Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.Protein-misfolding diseases and chaperone-based therapeutic approaches.Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.Prion diseases: from molecular biology to intervention strategies.Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.Mechanistic insights into the cure of prion disease by novel antiprion compounds Potent inhibition of tau fibrillization with a multivalent ligand.An overview of transmissible spongiform encephalopathies.QSAR study of anti-prion activity of 2-aminothiazoles.Tau-based treatment strategies in neurodegenerative diseases Small-molecule theranostic probes: a promising future in neurodegenerative diseases.Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.Multitarget ligands and theranostics: sharpening the medicinal chemistry sword against prion diseases.G-quadruplexes within prion mRNA: the missing link in prion disease?Modulation of prion protein oligomerization, aggregation, and beta-sheet conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS).Approaches for discovering anti-prion compounds: lessons learned and challenges ahead.Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.Rational approach to an antiprion compound with a multiple mechanism of action.Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life.Hybrid lipoic acid derivatives to attack prion disease on multiple fronts.The suppression of prion propagation using poly-L-lysine by targeting plasminogen that stimulates prion protein conversion.An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models.Cyclodextrins inhibit replication of scrapie prion protein in cell culture.Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments.Structure-activity relationship of cyclic thiacarbocyanine tau aggregation inhibitors.Prediction of antiprion activity of therapeutic agents with structure-activity models.[Creutzfeldt-Jakob disease, Heidenhain variant: case report with MRI (DWI) findings].

P2860

Q21090510-CF46E0A6-23FD-404A-A4FE-E08A391C7E96 Q24618566-7CE8D4A1-BE94-41DE-8B56-7B37EF9C517D Q24670553-823EC626-7F28-48A2-97FA-A3F9CF51F99E Q27677065-618C6B3C-A65C-48CD-9D1B-17A69CBC482C Q30784753-FC693368-8046-45B9-A6EF-A204FEA68372 Q31156724-13E9C930-4102-4A0D-B5CB-009D42FC7C71 Q33224951-6C5B65B6-BC98-4B2F-87C4-AFFFF2813A51 Q33279371-E5605B05-E754-42D5-B002-11817928996A Q33560026-E65F1332-E794-4E8D-8119-69F09FC03A04 Q33796040-E81B4ACA-32EF-4548-850E-3B304A2A27F3 Q34286572-4E7DBBAF-E5AF-4B2C-9A7A-F5AA5778DF44 Q34301832-C610C476-964A-4E3B-A75F-B40E2CEB7C6B Q34415659-F771F4CE-AAEE-4DDD-AF6E-A5ECA96AE174 Q34524526-19A90B7F-6278-4690-8251-8EA8798DC762 Q35030768-142CB09D-F2BD-4F8A-BB08-B0DE38D68363 Q35145020-EA6E8721-23F1-46C8-A3F4-9AA6E7D04A48 Q35602374-6F4EF606-FA4D-4383-994C-832550FB3334 Q35844090-57EA35ED-A571-42DD-8A10-2AA5C91E9035 Q36099134-95DFF38F-E49A-4279-88B9-A023750502B1 Q36103300-2A1FFEDF-CAD6-4722-8842-0F9E3D36BAB5 Q36177322-EE573CE7-F392-43FE-A3EA-00BC4A822B52 Q37089557-0E538D40-E853-4B31-9A3F-9F88F147A387 Q37215861-0A2D045D-725F-4F69-8C50-C053251BFED2 Q37353880-CCB475E6-4F03-4EA6-9642-72D63FC35FC2 Q37725318-8FC94F9F-9665-4B3C-9BD6-CE58D738D19B Q38234645-AB9E1F80-D1E2-441E-BE3A-DCD93F76786D Q38305734-C581BB4B-7428-46A3-8A18-CE47BB705A5E Q38347673-3EF54E51-04EE-42C0-8F8E-8522EFD8673E Q38356026-AC8E9B3B-2ACC-4122-96A0-2C7C6055B1B1 Q38718288-E58C2324-ED2B-40A0-B74F-2CB7F7173A0F Q38948910-83832F7A-B0F6-43FC-8011-0C1FDAE2D235 Q39326827-6E810F0C-7DCD-40A4-8B4D-1B3D42E178C2 Q39574917-24189E61-B918-475F-97F3-5481DF8AF7B8 Q39599032-0F27E7B5-4863-4BBC-919D-8502943224D3 Q39612001-ADCCFCFD-34FE-40D8-8BD6-E28023C6546E Q40093984-CB3390A7-74A2-404C-AFD8-F24E7E548A34 Q40272134-E2351D96-0912-46B7-99E3-95C447C47ED2 Q42060140-3EDC14B1-4442-470E-A8DE-E5FE99ACE2E3 Q43966734-324540A9-EC30-4549-B84A-AB25AC55B46A Q44965016-91E6CAE1-C137-43C9-BEE8-B1A8591C07F4

P2860

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

http://www.wikidata.org/entity/Q31134598

description

2003 nî lūn-bûn

@nan

2003 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի մարտին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

name

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

@ast

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

@en

type

label

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

@ast

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

@en

prefLabel

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

@ast

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

@en

P1433

Q31134598-E900BE70-BB5C-453E-AB0C-BB8B2D752086

P1476

Q31134598-9254185A-77BB-43CE-A5A7-CF8C235E3714

P2093

Q31134598-21D2E074-0046-4C53-B750-AFC4734FE264

Q31134598-3F2CB8ED-63E7-49B7-B80B-8DEAD2564EAA

Q31134598-A6DFB1F3-4F5C-4F61-BB55-80C63F23BEC4

Q31134598-C67DE40C-2046-4CCA-8313-FD29314BB9DD

Q31134598-FB5E6A62-6BDC-492E-9328-E372D717ED6F

P2860

Q31134598-015B3FF6-318D-4553-A63B-70DEE4D24967

Q31134598-196785E6-7300-492C-8BD4-31BBB5A0D41E

Q31134598-19806F47-B97D-4AD3-96A0-13E2C6E6230A

Q31134598-1F022C76-0550-47A9-887F-60CC2CF70903

Q31134598-2C7D890C-4E69-41B4-AA9A-B522353654D9

Q31134598-4567D7B0-4667-4BDE-8A2F-24A3538F4055

Q31134598-49A7D500-5043-47C0-B983-08F8EFEABD88

Q31134598-5FAB3B43-07C1-465B-80C6-BCC1C94B7955

Q31134598-6007B463-0272-43F8-86D7-9805D2671F63

Q31134598-6818311E-4243-4475-9C4B-F3E9789A818E

P304

Q31134598-D21EF9EC-E78C-4A61-8A57-4EABAC824E40

P31

Q31134598-42024321-A2EE-43EE-96A5-E76F8DF0D792

P356

Q31134598-B0C8FA27-5AE2-4291-A138-D4039A08E1E7

P407

Q31134598-6DDC858E-0817-4F96-9D3C-857B4E672E68

P433

Q31134598-2ADC07D8-CA93-4EC6-8D45-A89EAD660447

P478

Q31134598-D6119771-9985-4B64-8A4C-C0934E6E9E43

P50

Q31134598-AA15EEA1-7062-4DE8-9A9B-9BFF8C19019D

Q31134598-F5CB3528-0C9B-41F3-9652-8D6A8A73182D

P577

Q31134598-6D16F100-E063-4271-B2E5-1638DB56AD8C

P5875

Q31134598-302C00A8-CB42-44C0-81C2-7D93B4FAE248

P698

Q31134598-3BF02F5A-E73C-474E-BF27-4FC9EF5D13AC

P921

Q31134598-19F54B01-C28C-49F6-9068-AD9D389F419C

P932

Q31134598-8A04E03C-DA2D-4DF5-BACD-71A097029A30

P356

PNAS.2627988100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

@en

P2093

Aaron T Fafarman

http://www.w3.org/2001/XMLSchema#string

Barnaby C H May

http://www.w3.org/2001/XMLSchema#string

Leslie W Deady

http://www.w3.org/2001/XMLSchema#string

Michael Rogers

http://www.w3.org/2001/XMLSchema#string

Septima B Hong

http://www.w3.org/2001/XMLSchema#string

P2860

Prion Protein Biology

Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

Branched polyamines cure prion-infected neuroblastoma cells

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

Structural clues to prion replication.

Pharmacological approaches to prion research.

Drug therapy in human and experimental transmissible spongiform encephalopathy.

Therapeutic strategies for human amyloid diseases.

P304

3416-3421

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.2627988100

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

100

http://www.w3.org/2001/XMLSchema#string

P50

Stanley B. Prusiner

P577

2003-03-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10864850

http://www.w3.org/2001/XMLSchema#string

P698

12626750

http://www.w3.org/2001/XMLSchema#string

P921

Prion protein family

P932

152307

http://www.w3.org/2001/XMLSchema#string