Rational approach to an antiprion compound with a multiple mechanism of action.

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Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease.A promising anti-prion trimethoxychalcone binds to the globular domain of PrP(C) and changes its cellular location.Advances at the intersection of chemical biology and medicinal chemistry.

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P2860

Rational approach to an antiprion compound with a multiple mechanism of action.

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http://www.wikidata.org/entity/Q38948910

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Rational approach to an antiprion compound with a multiple mechanism of action.

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type

Item

label

Rational approach to an antiprion compound with a multiple mechanism of action.

@en

prefLabel

Rational approach to an antiprion compound with a multiple mechanism of action.

@en

P1476

Rational approach to an antiprion compound with a multiple mechanism of action.

@en

P2093

Federica Prati

http://www.w3.org/2001/XMLSchema#string

Giuseppe Legname

http://www.w3.org/2001/XMLSchema#string

Hoang Ngoc Ai Tran

http://www.w3.org/2001/XMLSchema#string

Maria Laura Bolognesi

http://www.w3.org/2001/XMLSchema#string

Suzana Aulic

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P2860

Continuous quinacrine treatment results in the formation of drug-resistant prions

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

Tetracyclines affect prion infectivity.

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

Clioquinol and other hydroxyquinoline derivatives inhibit Abeta(1-42) oligomer assembly.

Synthesis and evaluation of a library of 2,5-bisdiamino-benzoquinone derivatives as probes to modulate protein-protein interactions in prions.

Discovery of a class of diketopiperazines as antiprion compounds.

Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound.

Redox control of prion and disease pathogenesis.

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

P304

2113-2120

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scholarly article

P356

10.4155/FMC.15.79

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P433

http://www.w3.org/2001/XMLSchema#string

P478

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Paolo Carloni

Salvatore Bongarzone

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2015-10-29T00:00:00Z

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P698

26511069

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Rational approach to an antiprion compound with a multiple mechanism of action.

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P2860

P2860

Rational approach to an antiprion compound with a multiple mechanism of action.

description

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type

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prefLabel

P1433

P1476

P2093

P2860

P304

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P356

P433

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P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698