Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays.
about
The role of HDAC6 in cancerDiversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryInhibition of the function of class IIa HDACs by blocking their interaction with MEF2HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeuticsA systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological dataA semi-supervised method for drug-target interaction prediction with consistency in networksLarge-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug RepurposingDiversity-oriented synthesis: exploring the intersections between chemistry and biology.Targeted delivery of multifunctional magnetic nanoparticles.A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myelomaTubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.Synapse microarray identification of small molecules that enhance synaptogenesis.Epigenetic changes induced by curcumin and other natural compounds.Diversity-oriented synthesis: producing chemical tools for dissecting biology.The use of novel agents in the treatment of relapsed and refractory multiple myelomaIn-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics.Large-scale Direct Targeting for Drug Repositioning and Discovery.Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules.Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Discovery of histone deacetylase 8 selective inhibitors.Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myelomaEmerging challenges in ligand discovery: new opportunities for chromatographic assay.HDAC6 and ovarian cancer.Exploring the ligand-protein networks in traditional chinese medicine: current databases, methods, and applicationsThe aggresome pathway as a target for therapy in hematologic malignancies.Isoform-selective histone deacetylase inhibitorsPrediction of drug-target interaction networks from the integration of chemical and genomic spaces.Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.Targeting histone deacetylases for the treatment of diseaseSupervised prediction of drug-target interactions using bipartite local models.Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib.Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity.Perspectives on natural product epigenetic modulators in chemical biology and medicine.Similarity-based machine learning methods for predicting drug-target interactions: a brief review.Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia.Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy.
P2860
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P2860
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Multidimensional chemical gene ...... itors using cell-based assays.
@ast
Multidimensional chemical gene ...... itors using cell-based assays.
@en
type
label
Multidimensional chemical gene ...... itors using cell-based assays.
@ast
Multidimensional chemical gene ...... itors using cell-based assays.
@en
prefLabel
Multidimensional chemical gene ...... itors using cell-based assays.
@ast
Multidimensional chemical gene ...... itors using cell-based assays.
@en
P2093
P1476
Multidimensional chemical gene ...... itors using cell-based assays.
@en
P2093
Jason C Wong
Kathryn M Koeller
Rebecca A Butcher
Stephen J Haggarty
Stuart L Schreiber
P304
P356
10.1016/S1074-5521(03)00095-4
P577
2003-05-01T00:00:00Z