Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
about
The role of HDAC6 in cancerHEF1-dependent Aurora A activation induces disassembly of the primary ciliumHistone deacetylase inhibitors: Potential in cancer therapyClinical use and applications of histone deacetylase inhibitors in multiple myelomaClinical developments in the treatment of relapsed or relapsed and refractory multiple myeloma: impact of panobinostat, the first-in-class histone deacetylase inhibitorNovel agents for multiple myeloma to overcome resistance in phase III clinical trialsHistone deacetylase 6 plays a role as a distinct regulator of diverse cellular processesNew and emerging HDAC inhibitors for cancer treatmentMice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.Clinical use of proteasome inhibitors in the treatment of multiple myelomaNovel therapeutic strategies for multiple myelomaHistone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancyAggresome formation and neurodegenerative diseases: therapeutic implicationsDevelopment of a histone deacetylase 6 inhibitor and its biological effectsReversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathwaysParkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitorsInhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cellsHDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytesThe novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivoCarbamate prodrug concept for hydroxamate HDAC inhibitors.Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma.TANDEM: a two-stage approach to maximize interpretability of drug response models based on multiple molecular data types.Targeting the UPS as therapy in multiple myeloma.Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors.Panobinostat in lymphoid and myeloid malignancies.Deacetylase inhibitors: an advance in myeloma therapy?Clinical Pharmacokinetics and Pharmacodynamics of Panobinostat.IIp45 inhibits cell migration through inhibition of HDAC6Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibilityTPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells.Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation.New strategies in the treatment of multiple myeloma.Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.Protein quality control during erythropoiesis and hemoglobin synthesisA novel class of small molecule inhibitors of HDAC6.Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.
P2860
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P2860
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Small-molecule inhibition of p ...... r activity in multiple myeloma
@ast
Small-molecule inhibition of p ...... r activity in multiple myeloma
@en
type
label
Small-molecule inhibition of p ...... r activity in multiple myeloma
@ast
Small-molecule inhibition of p ...... r activity in multiple myeloma
@en
prefLabel
Small-molecule inhibition of p ...... r activity in multiple myeloma
@ast
Small-molecule inhibition of p ...... r activity in multiple myeloma
@en
P2093
P2860
P356
P1476
Small-molecule inhibition of p ...... r activity in multiple myeloma
@en
P2093
Dharminder Chauhan
James E Bradner
Jason Wong
Stuart L Schreiber
Teru Hideshima
P2860
P304
P356
10.1073/PNAS.0503221102
P407
P577
2005-06-03T00:00:00Z