5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
about
Kappa opioid antagonists: past successes and future prospectsFlavonoids as opioid receptor ligands: identification and preliminary structure-activity relationshipsAntagonists of the kappa-opioid receptor enhance allodynia in rats and mice after sciatic nerve ligationLong-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinaseMolecular switches of the κ opioid receptor triggered by 6'-GNTI and 5'-GNTI.A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptorsKappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependenceAnalogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activityProdynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsRoles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor.N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonistsActivation of the opioid μ1, but not δ or κ, receptors is required for nicotine reinforcement in a rat model of drug self-administration.Major Depressive Disorder and Kappa Opioid Receptor Antagonists.Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward.Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.Development of κ opioid receptor antagonists.Dynorphin and the pathophysiology of drug addiction.Electroacupuncture Attenuates 5'-Guanidinonaltrindole-Evoked Scratching and Spinal c-Fos Expression in the Mouse.Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain modelsNatural products as tools for neuroscience: discovery and development of novel agents to treat drug abuseDevelopment of functionally selective, small molecule agonists at kappa opioid receptors.Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands.Nalfurafine prevents 5'-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice.Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence.Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection.Effect of GNTI, a kappa opioid receptor antagonist, on MK-801-induced hyperlocomotion and stereotypy in mice.Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.Renal responses to the kappa-opioid-receptor agonist U-50488H in conscious lambs.Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels.Structure-activity relationships of arodyn, a novel acetylated kappa opioid receptor antagonist.Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny.
P2860
Q24647830-E03CD5F5-7C5B-4751-B08B-8914CC65E35AQ24655806-3EE60A1E-57C6-47C0-8517-B3EF7CAF5123Q24672417-629C714E-E5AC-41C2-B2C8-26EBD8660515Q24685243-B680CA63-03D0-4B85-B3A0-2262090DB2C8Q27302413-3418F39E-2AEB-473E-9BFB-A29051B70620Q28822182-BAB53C8C-63F7-40AB-8AF2-4CF2DC81FA47Q30453617-C7C02E7D-0327-4513-AA9C-374040FCE9FDQ30474756-62CF3444-76F2-4CEA-BD87-81F25D890954Q30481448-4BAB9ED9-DBA1-477D-90B0-0DC860AF1F7AQ30486707-3DC40662-E90F-4679-A252-D0D1C3DF31ABQ34399121-0EB0CEC7-B0B9-41E6-A5CE-E3BA23BE480FQ34478208-5CB44436-87C9-4BD4-864E-749BBA28F436Q34482188-10A9DE9D-8DC3-462E-95D8-2D19D75AB04EQ34527874-1F1D0089-E441-44AC-921F-B246BE06BFFBQ34847745-A3F5FD1C-F2BF-481A-9D00-E5EE6E75C722Q36305030-FCE87C41-DB82-482B-99B9-34EB2A47E970Q36728154-0FE4250B-50BF-464C-BD32-5A4985364F63Q36942175-71AFCA36-B6DC-40D6-AEBF-7AF625805339Q37002814-371594D8-5D93-436C-82A0-633AB406DC51Q37220686-C68B1A7A-AC39-4840-AABC-AAFCAFCD37F3Q37355904-353E348A-58CD-40AB-B26D-33205CE6BCDAQ37405071-A1041D4E-0F17-4996-BEB5-7D9B433867D7Q41639865-82595F95-2449-41F5-B90A-917A2DDAEC41Q41872689-C01E98FF-A7CC-4C10-AE40-F55E04921B90Q41948109-46D00B50-63C2-4F78-8C66-2D98B93722A9Q42540243-02CE5BB3-DBB2-4264-BD74-C3FAFD2F23AEQ42540483-2957A4F2-4D31-40C7-9EAA-74C566144405Q44088641-BFC2B8DC-111E-4636-9711-49568516BE5AQ44332455-26270005-4604-45FC-8851-FEB033ABD781Q44334254-D12C499A-6DE9-4318-917B-E2E15E0028AEQ44334609-7A122C6E-012C-4C27-A3DB-E6D324F9739EQ44341449-25BFBA13-8B6E-43B2-8D1C-11695D20D197Q44348482-BEB7A703-541D-49D2-9648-16165851EE61Q55564405-74640F56-57FF-4303-9B37-2A8EDCC75909
P2860
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
name
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
@ast
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
@en
type
label
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
@ast
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
@en
prefLabel
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
@ast
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
@en
P1476
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
@en
P2093
Portoghese PS
P356
10.1016/S0014-2999(00)00208-9
P407
P577
2000-05-01T00:00:00Z