A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.
about
A novel type of allosteric regulation: functional cooperativity in monomeric proteinsModeling kinetic data from in vitro drug metabolism enzyme experiments.Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sitesNRF2, cancer and calorie restrictionThe role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism.Analysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone.Inhibition of human cytochrome P450 3A4 by cholesterolAllosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysisProgress towards prediction of human pharmacokinetic parameters from in vitro technologies.Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.Cytochrome P450: what have we learned and what are the future issues?"Allosterism" in the elementary steps of the cytochrome P450 reaction cycle.Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4Inhibition of CYP2B4 by 2-ethynylnaphthalene: evidence for the co-binding of substrate and inhibitor within the active site.Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomerQM/MM study of the active species of the human cytochrome P450 3A4, and the influence thereof of the multiple substrate binding.Cooperative properties of cytochromes P450.Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures.Identifying and characterizing promiscuous targets: implications for virtual screening.Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4Simultaneous evaluation of substrate-dependent CYP3A inhibition using a CYP3A probe substrates cocktail.Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.In vitro and in vivo metabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys.Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations.Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam.Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps.Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol.Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.Membrane-embedded substrate recognition by cytochrome P450 3A4.
P2860
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P2860
A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A kinetic model for the metabo ...... e site of cytochrome P450 3A4.
@ast
A kinetic model for the metabo ...... e site of cytochrome P450 3A4.
@en
type
label
A kinetic model for the metabo ...... e site of cytochrome P450 3A4.
@ast
A kinetic model for the metabo ...... e site of cytochrome P450 3A4.
@en
prefLabel
A kinetic model for the metabo ...... e site of cytochrome P450 3A4.
@ast
A kinetic model for the metabo ...... e site of cytochrome P450 3A4.
@en
P2093
P2860
P356
P1476
A kinetic model for the metabo ...... e site of cytochrome P450 3A4.
@en
P2093
P2860
P304
P356
10.1074/JBC.M008799200
P407
P577
2000-10-27T00:00:00Z