Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics
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Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligandUnderstanding the mechanism of cytochrome P450 3A4: recent advances and remaining problemsA novel type of allosteric regulation: functional cooperativity in monomeric proteinsCrystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativityPotent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 CatalysisInteraction of human cytochrome P4503A4 with ritonavir analogsInfluence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylaseRedox potential control by drug binding to cytochrome P450 3A4Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes).A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe.Experimental approaches to evaluate activities of cytochromes P450 3AAllosteric phenomena in cytochrome P450-catalyzed monooxygenations.Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.Analysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone.Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes.Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity.Structural basis for ligand promiscuity in cytochrome P450 3A4.Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequencesA large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).Cytochrome P450: what have we learned and what are the future issues?Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand InteractionsEnergetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4On the putative co-transport of drugs by multidrug resistance proteins.Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomerConformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR SpectroscopyCharacterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry.Understanding cooperativity in human p450 mediated drug-drug interactions.QM/MM study of the active species of the human cytochrome P450 3A4, and the influence thereof of the multiple substrate binding.Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.Substrate binding to cytochromes P450.Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone.Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.Cooperative properties of cytochromes P450.The structural basis of pregnane X receptor binding promiscuity.
P2860
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P2860
Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Analysis of human cytochrome P ...... steroid hydroxylation kinetics
@ast
Analysis of human cytochrome P ...... steroid hydroxylation kinetics
@en
type
label
Analysis of human cytochrome P ...... steroid hydroxylation kinetics
@ast
Analysis of human cytochrome P ...... steroid hydroxylation kinetics
@en
prefLabel
Analysis of human cytochrome P ...... steroid hydroxylation kinetics
@ast
Analysis of human cytochrome P ...... steroid hydroxylation kinetics
@en
P2860
P356
P1476
Analysis of human cytochrome P ...... steroid hydroxylation kinetics
@en
P2093
G R Harlow
J R Halpert
P2860
P304
P356
10.1073/PNAS.95.12.6636
P407
P577
1998-06-01T00:00:00Z