Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
about
Gold(I)-triphenylphosphine complexes with hypoxanthine-derived ligands: in vitro evaluations of anticancer and anti-inflammatory activitiesDNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapySubstitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.Conserved molecular mechanisms underlying the effects of small molecule xenobiotic chemotherapeutics on cells.Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT).Scope of the ring-opening metathesis polymerization (ROMP) reaction of 1-substituted cyclobutenes.Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma.
P2860
Q28543014-95AD8BAC-A162-4435-9641-200AF106C48AQ36012002-5B10DEBC-2A2F-498F-8E00-4A3C54B7D0FFQ37105014-BBA1CE0F-17D0-4335-AB71-FC6FEA7E4757Q38719813-B41CA5A1-258D-4D97-8572-43341DDA343BQ40680395-ED6C4FD6-A5C5-4066-A843-BE0FC18D5B62Q41771536-4F5DCB04-2745-451F-B0B2-DE11B1CE0A31Q42534045-259448C1-354B-4BF0-B952-F3B4709E73D8Q48124327-91FE1B6B-17F7-4F38-8C2A-ADE54D24D56EQ55139727-56EB3B1B-FAA8-44BD-887D-F7CADE544483
P2860
Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Resistance-modifying agents. 8 ...... 1-cyclopentenylmethyl)guanine.
@ast
Resistance-modifying agents. 8 ...... 1-cyclopentenylmethyl)guanine.
@en
type
label
Resistance-modifying agents. 8 ...... 1-cyclopentenylmethyl)guanine.
@ast
Resistance-modifying agents. 8 ...... 1-cyclopentenylmethyl)guanine.
@en
prefLabel
Resistance-modifying agents. 8 ...... 1-cyclopentenylmethyl)guanine.
@ast
Resistance-modifying agents. 8 ...... 1-cyclopentenylmethyl)guanine.
@en
P2093
P356
P1476
Resistance-modifying agents. 8 ...... 1-cyclopentenylmethyl)guanine.
@en
P2093
A H Calvert
B T Golding
C Bleasdale
D R Newell
N J Curtin
N K Lembicz
P304
P356
10.1021/JM000961O
P407
P577
2000-11-01T00:00:00Z