Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.

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The potential of combi-molecules with DNA-damaging function as anticancer agents.Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU.

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Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

@zh-hk

2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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Identification of the Structur ...... mbined with Molecular Docking.

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Identification of the Structur ...... mbined with Molecular Docking.

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Identification of the Structur ...... mbined with Molecular Docking.

@en

P1476

Identification of the Structur ...... mbined with Molecular Docking.

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P2093

Guohui Sun

http://www.w3.org/2001/XMLSchema#string

Lijiao Zhao

http://www.w3.org/2001/XMLSchema#string

Na Zhang

http://www.w3.org/2001/XMLSchema#string

Rugang Zhong

http://www.w3.org/2001/XMLSchema#string

Tengjiao Fan

http://www.w3.org/2001/XMLSchema#string

Ting Ren

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P2860

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

Beware of q2!

Improved protein-ligand docking using GOLD

Comparative molecular similarity index analysis (CoMSIA) to study hydrogen-bonding properties and to score combinatorial libraries.

Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships.

Rational selection of training and test sets for the development of validated QSAR models.

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.

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scholarly article

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10.3390/MOLECULES21070823

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English

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2016-06-23T00:00:00Z

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27347909

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6273773

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Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.

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P2860

P2860

Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.

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P1433

P1476

P2093

P2860

P31

P356

P407

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P31

P356

P407

P433

P478

P577

P698

P932