The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
about
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsPhosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function.NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells.Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.Direct activation of ATM by resveratrol under oxidizing conditions.The flavonoid beverage Haelan 951 induces growth arrest and apoptosis in pancreatic carcinoma cell lines in vitroPathway-specific effect of caffeine on protection against UV irradiation-induced apoptosis in corneal epithelial cells.Stress-induced corneal epithelial apoptosis mediated by K+ channel activationSelective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib.Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway.Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity.Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7.Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells.Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppressionInvolvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest.Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts.
P2860
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P2860
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
@ast
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
@en
type
label
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
@ast
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
@en
prefLabel
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
@ast
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
@en
P2093
P2860
P356
P1476
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
@en
P2093
P2860
P304
P356
10.1074/JBC.M004894200
P407
P577
2000-11-28T00:00:00Z