Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.
about
CP-31398, a putative p53-stabilizing molecule tested in mammalian cells and in yeast for its effects on p53 transcriptional activityChemical Variations on the p53 Reactivation ThemeTumor suppressor p53 and its gain-of-function mutants in cancerRegulation of protein quality control by UBE4B and LSD1 through p53-mediated transcriptionAttenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 functionImplementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.Targeting p53 for Novel Anticancer Therapy.SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Paradoxical suppression of cellular senescence by p53Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis.Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.p53 Family and Cellular Stress Responses in Cancer.The role of p53 in chemosensitivity and radiosensitivity.TRAIL and apoptosis induction by TNF-family death receptors.Translational approaches targeting the p53 pathway for anti-cancer therapy.Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action.Insulin-like growth factor factor binding protein-2 is a novel mediator of p53 inhibition of insulin-like growth factor signaling.CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice.Targeting mutant p53 shows promise for sunscreens and skin cancerStrategies for therapeutic targeting of the p53 pathway in cancer.Reactivation of mutant p53: molecular mechanisms and therapeutic potential.Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo.Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ miceRescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptideChemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice.Pharmacological activation of p53 in cancer cellsTargeting the p53 pathway.Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats.p53-based cancer therapyCell cycle inhibitors for the treatment of NSCLC.Oncoapoptotic markers in oral cancer: prognostics and therapeutic perspective.Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells.The Wilms tumor suppressor-1 target gene podocalyxin is transcriptionally repressed by p53.Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents.CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo.CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo.Reviving the guardian of the genome: Small molecule activators of p53.Mutant p53 melanoma cell lines respond differently to CP-31398-induced apoptosis.
P2860
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P2860
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@ast
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@en
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@nl
type
label
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@ast
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@en
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@nl
prefLabel
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@ast
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@en
Stabilization of p53 by CP-313 ...... rine 15 or 20 or MDM2 binding.
@nl
P2093
P2860
P1476
Stabilization of p53 by CP-313 ...... erine 15 or 20 or MDM2 binding
@en
P2093
Farzan Rastinejad
Rishu Takimoto
Wenge Wang
P2860
P304
P356
10.1128/MCB.23.6.2171-2181.2003
P407
P577
2003-03-01T00:00:00Z