mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.
about
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEPNegative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic WindowGlucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injuryNeuroimaging in traumatic brain imaging.Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.The effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia.The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease.Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans.Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.Therapeutic potential of mGluR5 targeting in Alzheimer's diseaseDouble Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors.Transcriptional profiling reveals regulated genes in the hippocampus during memory formation.The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathwayAttenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine.Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actionsMetabotropic glutamate receptor ligands as potential therapeutics for addictionDeveloping neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction.A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats.Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation.Metabotropic glutamate receptor 5 deficiency inhibits neutrophil infiltration after traumatic brain injury in mice.Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications.
P2860
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P2860
mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.
description
2001 nî lūn-bûn
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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
mGluR5 antagonists 2-methyl-6- ...... -methyl-D-aspartate receptors.
@ast
mGluR5 antagonists 2-methyl-6- ...... -methyl-D-aspartate receptors.
@en
type
label
mGluR5 antagonists 2-methyl-6- ...... -methyl-D-aspartate receptors.
@ast
mGluR5 antagonists 2-methyl-6- ...... -methyl-D-aspartate receptors.
@en
prefLabel
mGluR5 antagonists 2-methyl-6- ...... -methyl-D-aspartate receptors.
@ast
mGluR5 antagonists 2-methyl-6- ...... -methyl-D-aspartate receptors.
@en
P2093
P1476
mGluR5 antagonists 2-methyl-6- ...... -methyl-D-aspartate receptors.
@en
P2093
D M O'Leary
P G Mullins
S M Knoblach
V A Movsesyan
P407
P577
2001-01-01T00:00:00Z