Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
about
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosomeDissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsThe Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification PathwayDual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovaniMitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activityMolecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetaseStage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovaniBis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.Biosynthesis of trypanothione in Trypanosoma brucei brucei.Glutathionylation of trypanosomal thiol redox proteins.The parasite-specific trypanothione metabolism of trypanosoma and leishmania.Trypanothione synthesis in crithidia revisited.Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.Molecular mechanisms of in vitro betulin-induced apoptosis of Leishmania donovani.Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis.Iron metabolism in trypanosomatids, and its crucial role in infection.Polyamine metabolism in Leishmania: from arginine to trypanothione.Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes.The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes.Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin.The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism.Overexpression of mitochondrial Leishmania major ascorbate peroxidase enhances tolerance to oxidative stress-induced programmed cell death and protein damage.Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression.Catalytic properties, thiol pK value, and redox potential of Trypanosoma brucei tryparedoxin.A second class of peroxidases linked to the trypanothione metabolism.Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam.Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei.Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.The cytosolic or the mitochondrial glutathione peroxidase-type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron-mediated mitochondrial damage and lysis.Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death
P2860
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P2860
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Trypanothione-dependent synthe ...... ucei ribonucleotide reductase.
@ast
Trypanothione-dependent synthe ...... ucei ribonucleotide reductase.
@en
type
label
Trypanothione-dependent synthe ...... ucei ribonucleotide reductase.
@ast
Trypanothione-dependent synthe ...... ucei ribonucleotide reductase.
@en
prefLabel
Trypanothione-dependent synthe ...... ucei ribonucleotide reductase.
@ast
Trypanothione-dependent synthe ...... ucei ribonucleotide reductase.
@en
P2093
P2860
P356
P1476
Trypanothione-dependent synthe ...... ucei ribonucleotide reductase.
@en
P2093
Dormeyer M
Krauth-Siegel RL
Ludemann H
Reckenfelderbäumer N
P2860
P304
10602-10606
P356
10.1074/JBC.M010352200
P407
P577
2001-01-09T00:00:00Z