Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.
about
The remarkable transport mechanism of P-glycoprotein: a multidrug transporter.Exploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunitiesElf1p, a member of the ABC class of ATPases, functions as a mRNA export factor in Schizosacchromyces pombe.Structural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopyPluronics and MDR reversal: an update.Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeableHow are the ABC transporters energized?ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformationModulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranesDrug resistance in cancer: an overview.The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux.Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transportersSelective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy.Functional characterization of Candida albicans ABC transporter Cdr1p.ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart.The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely togetherUse of chimeric proteins to investigate the role of transporter associated with antigen processing (TAP) structural domains in peptide binding and translocation.The translocation mechanism of P-glycoprotein.Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding.Characterization of the adenosinetriphosphatase and transport activities of purified cystic fibrosis transmembrane conductance regulator.Biochemical mechanism of modulation of human P-glycoprotein by stemofolineCLC-0 and CFTR: chloride channels evolved from transporters.Exploring conformational equilibria of a heterodimeric ABC transporter.Marine natural products with P-glycoprotein inhibitor properties.Various drug delivery approaches to the central nervous system.Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance.Current strategies for targeted delivery of bio-active drug molecules in the treatment of brain tumor.Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP).Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance.Role of nanomedicine in reversing drug resistance mediated by ATP binding cassette transporters and P-glycoprotein in melanoma.Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein.Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transpoPermanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.Optimizing chemotherapy by measuring reversal of P-glycoprotein activity in plasma membrane vesicles.
P2860
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P2860
Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Characterization of the cataly ...... different functional outcomes.
@ast
Characterization of the cataly ...... different functional outcomes.
@en
type
label
Characterization of the cataly ...... different functional outcomes.
@ast
Characterization of the cataly ...... different functional outcomes.
@en
prefLabel
Characterization of the cataly ...... different functional outcomes.
@ast
Characterization of the cataly ...... different functional outcomes.
@en
P2860
P356
P1476
Characterization of the cataly ...... different functional outcomes.
@en
P2093
P2860
P304
11653-11661
P356
10.1074/JBC.M011294200
P407
P577
2001-01-11T00:00:00Z