Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility.
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Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmiasIn cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingKinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparksDysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseasesInteraction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domainDoxapram hydrochloride aggravates adrenaline-induced arrhythmias accompanied by bidirectional ventricular tachycardiaDissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytesTriadin (Trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubesFKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cellsFKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes.The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms?Deciphering ryanodine receptor array operation in cardiac myocytes.FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium releaseExcitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach.Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.Targeting cardiomyocyte Ca2+ homeostasis in heart failure.Models of dilated cardiomyopathy in small animals and novel positive inotropic therapies.Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice.Targeting altered calcium physiology in the heart: translational approaches to excitation, contraction, and transcription.Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions.Ryanodine receptor-mediated arrhythmias and sudden cardiac death.Designing heart performance by gene transfer.Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6.Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death.From eggs to hearts: what is the link between cyclic ADP-ribose and ryanodine receptors?Cardiac inotropes: current agents and future directions.Total internal reflectance fluorescence imaging of genetically engineered ryanodine receptor-targeted Ca2+ probes in rat ventricular myocytes.FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge.The effects of over-expression of the FK506-binding protein FKBP12.6 on K(+) currents in adult rabbit ventricular myocytes.FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation.Defects in ryanodine receptor function are associated with systolic dysfunction in rats subjected to volume overload.FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels.A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure.In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy.Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger.Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes.Recent findings into the potential of gene therapy to reverse heart failure.
P2860
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P2860
Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Overexpression of FK506-bindin ...... m and increases contractility.
@ast
Overexpression of FK506-bindin ...... m and increases contractility.
@en
type
label
Overexpression of FK506-bindin ...... m and increases contractility.
@ast
Overexpression of FK506-bindin ...... m and increases contractility.
@en
prefLabel
Overexpression of FK506-bindin ...... m and increases contractility.
@ast
Overexpression of FK506-bindin ...... m and increases contractility.
@en
P2093
P356
P1433
P1476
Overexpression of FK506-bindin ...... m and increases contractility.
@en
P2093
Hasenfuss G
Janssen AP
Janssen PM
Lehnart SE
P304
P356
10.1161/01.RES.88.2.188
P577
2001-02-01T00:00:00Z