Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin.

Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin.

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http://www.wikidata.org/entity/Q31917609

Q31917609

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Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease Image-guided convection-enhanced delivery platform in the treatment of neurological diseases.In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system.Neurturin effects on nigrostriatal dopamine release and content: comparison with GDNF New methods for direct delivery of chemotherapy for treating brain tumors.Titer and product affect the distribution of gene expression after intraputaminal convection-enhanced delivery.Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors Neurturin protects against 6-hydroxydopamine-induced reductions in evoked dopamine overflow in rat striatum.Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours.In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate.Diffusion of macromolecules in the brain: implications for drug delivery.Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation.Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents.Diffusion in brain extracellular space.Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.Trophic factors therapy in Parkinson's disease.Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro.The use of convection-enhanced delivery with liposomal toxins in neurooncology.Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations.Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence.The first cysteine-rich domain of the receptor GFRalpha1 stabilizes the binding of GDNF Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging.Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain.Neurturin overexpression in dopaminergic neurons induces presynaptic and postsynaptic structural changes in rats with chronic 6-hydroxydopamine lesion.Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats.Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.Structure and biophysical characterisation of the human full-length Neurturin-GFRa2 complex - a role for heparan sulfate in signalling.Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS

P2860

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P2860

Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin.

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http://www.wikidata.org/entity/Q31917609

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