The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. - Wikidata - wikimedia - TriplyDB

The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.

The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.

http://www.wikidata.org/entity/Q37313963

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Biology of adeno-associated viral vectors in the central nervous system A new look at cerebrospinal fluid circulation A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.Aβ Clearance, "hub" of Multiple Deficiencies Leading to Alzheimer Disease Gene-based therapy of Parkinson's Disease: Translation from animal model to human clinical trial employing convection enhanced delivery Interaction between therapeutic interventions for Alzheimer's disease and physiological Aβ clearance mechanisms Cytoplasmic electric fields and electroosmosis: possible solution for the paradoxes of the intracellular transport of biomolecules Axonal transport of AAV9 in nonhuman primate brain.The Glymphatic System: A Beginner's Guide MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor A new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug delivery Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor.Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes.Gene transfer corrects acute GM2 gangliosidosis--potential therapeutic contribution of perivascular enzyme flow Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?Image-guided convection-enhanced delivery platform in the treatment of neurological diseases.Future applications: gene therapy.AAV provides an alternative for gene therapy of the peripheral sensory nervous system.Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates Convection Enhanced Delivery: A Comparison of infusion characteristics in ex vivo and in vivo non-human primate brain tissue Anatomical differences determine distribution of adenovirus after convection-enhanced delivery to the rat brain.Guided delivery of adeno-associated viral vectors into the primate brain Imaging of cells and nanoparticles: implications for drug delivery to the brain.Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice.Impairment of paravascular clearance pathways in the aging brain.Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice.Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence.Predictive models for pressure-driven fluid infusions into brain parenchyma.Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex.Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease.Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 Tesla MRI.Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective.Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.Nonviral approaches for neuronal delivery of nucleic acids.Gene therapy for misfolding protein diseases of the central nervous system.Pathways of infusate loss during convection-enhanced delivery into the putamen nucleus Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease.

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The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.

http://www.wikidata.org/entity/Q37313963

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scientific article published on 02 May 2006

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The "perivascular pump" driven ...... ic molecules within the brain.

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The "perivascular pump" driven ...... ic molecules within the brain.

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The "perivascular pump" driven ...... ic molecules within the brain.

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The "perivascular pump" driven ...... ic molecules within the brain.

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J.YMTHE.2006.02.018

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Molecular Therapy

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The "perivascular pump" driven ...... ic molecules within the brain.

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Charles Noble

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Hanna Mirek

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John W Park

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Krystof Bankiewicz

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Laszlo Tamas

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Martha C Bohn

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Piotr Hadaczek

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Yoji Yamashita

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P2860

Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease

Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin.

Combined injection of rAAV with mannitol enhances gene expression in the rat brain.

Pseudorabies virus membrane proteins gI and gE facilitate anterograde spread of infection in projection-specific neurons in the rat.

Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space.

Rapid solute transport throughout the brain via paravascular fluid pathways.

Recombinant adeno-associated virus vector: use for transgene expression and anterograde tract tracing in the CNS

Recent advances in the use of neurotropic viruses for circuit analysis.

Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement.

Anterograde, transneuronal transport of herpes simplex virus type 1 strain H129 in the murine visual system.

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