Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
about
Virus maturation as a new HIV-1 therapeutic targetThe roles of genetic polymorphisms and human immunodeficiency virus infection in lipid metabolismCurrent and potential treatments for ubiquitous but neglected herpesvirus infectionsDistribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in MaturationPrecise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic WavesThe Role of Medical Structural Genomics in Discovering New Drugs for Infectious DiseasesStructural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PROptimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitorsX-Ray Crystal Structures of Human Immunodeficiency Virus Type 1 Protease Mutants Complexed with AtazanavirDesign and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2‘ Ligands in Pseudosymmetric Dipeptide IsosteresStructural Evidence for Effectiveness of Darunavir and Two Related Antiviral Inhibitors against HIV-2 ProteaseStructure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallographyMolecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor DarunavirStructure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypesCrystal Structures of Inhibitor Complexes of Human T-Cell Leukemia Virus (HTLV-1) ProteaseCrystal structure of XMRV protease differs from the structures of other retropepsinsJoint X-ray/Neutron Crystallographic Study of HIV-1 Protease with Clinical Inhibitor Amprenavir: Insights for Drug DesignGS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid InsertionsInhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatinCarbamylation of N-Terminal ProlineThermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteasesTracing binding modes in hit-to-lead optimization: chameleon-like poses of aspartic protease inhibitorsThymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymesLipopeptides as dimerization inhibitors of HIV-1 proteaseVirtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and VinaEvidence that the Bacillus subtilis SpoIIGA protein is a novel type of signal-transducing aspartic proteaseApplying sequential forward floating selection to protein structure prediction with a study of HIV-1 PR.Teaching foundational topics and scientific skills in biochemistry within the conceptual framework of HIV protease.Bioinformatics and Drug Discovery.Search and discovery strategies for biotechnology: the paradigm shift.The aspartic proteinase family of three Phytophthora species.HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations.Genetic selection for dissociative inhibitors of designated protein-protein interactions.Understanding HIV-1 protease autoprocessing for novel therapeutic development.Molecular docking studies of dithionitrobenzoic acid and its related compounds to protein disulfide isomerase: computational screening of inhibitors to HIV-1 entry.Mining the protein data bank to differentiate error from structural variation in clustered static structures: an examination of HIV protease.Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease.Computational study of the resistance shown by the subtype B/HIV-1 protease to currently known inhibitors.Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes.
P2860
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P2860
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
@ast
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
@en
type
label
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
@ast
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
@en
prefLabel
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
@ast
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
@en
P1476
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
@en
P2093
Vondrasek J
Wlodawer A
P304
P356
10.1146/ANNUREV.BIOPHYS.27.1.249
P577
1998-01-01T00:00:00Z