HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.
about
Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxiaHypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasmOxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor proteinIncreased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.Comparative transcriptomic and proteomic analyses provide insights into the key genes involved in high-altitude adaptation in the Tibetan pigThe hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.Novel therapies for renal cell carcinoma.Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL.Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cellsHypoxia-inducible factor (HIF1α) gene expression in human shock states.Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling.Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours.The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.Deferroxamine preconditioning promotes long-lasting retinal ischemic tolerance.Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.bcl-2/Adenovirus E1B 19-kd interacting protein 3 (BNIP3) regulates hypoxia-induced neural precursor cell death.Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective.Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.Precision medicine in pheochromocytoma and paraganglioma: current and future concepts.HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells.Phosphatidylinositol 3'-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1(alpha) and vascular endothelial growth factor expression.Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1).Endogenous 2-oxoacids differentially regulate expression of oxygen sensors.Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts.The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen.Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia.Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene.Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation.Lipopolysaccharide and hypoxia-induced HIF-1 activation in human gingival fibroblasts.Expression of hypoxia inducible factor-1α and its significance in laryngeal carcinoma.Hypoxia-inducible factor-1alpha accumulation in the brain after experimental intracerebral hemorrhage.NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells.Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond.Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat.Acute and chronic effect of sprint interval training combined with postexercise blood-flow restriction in trained individuals.
P2860
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P2860
HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
HIF-1-dependent transcriptiona ...... diated HIF-1alpha degradation.
@ast
HIF-1-dependent transcriptiona ...... diated HIF-1alpha degradation.
@en
type
label
HIF-1-dependent transcriptiona ...... diated HIF-1alpha degradation.
@ast
HIF-1-dependent transcriptiona ...... diated HIF-1alpha degradation.
@en
prefLabel
HIF-1-dependent transcriptiona ...... diated HIF-1alpha degradation.
@ast
HIF-1-dependent transcriptiona ...... diated HIF-1alpha degradation.
@en
P2093
P1433
P1476
HIF-1-dependent transcriptiona ...... diated HIF-1alpha degradation.
@en
P2093
P356
10.1016/S0014-5793(01)02159-7
P407
P577
2001-02-01T00:00:00Z