Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.
about
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivoThe apicomplexan plastid and its evolutionAnti-malarial Drug Design by Targeting Apicoplasts: New PerspectivesClinically Available Medicines Demonstrating Anti-Toxoplasma ActivityStructural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductaseX-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacyType I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structureDesign and Synthesis of Aryl Ether Inhibitors of theBacillus AnthracisEnoyl-ACP ReductaseIdentification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl ReductaseThe benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme targetDual-resolution molecular dynamics simulation of antimicrobials in biomembranesTriclosan: current status, occurrence, environmental risks and bioaccumulation potentialMultivariate PLS Modeling of Apicomplexan FabD-Ligand Interaction Space for Mapping Target-Specific Chemical Space and Pharmacophore FingerprintsDelivery of antimicrobials into parasitesAbsorption, pharmacokinetics, and safety of triclosan after dermal administration.Enzymes of type II fatty acid synthesis and apicoplast differentiation and division in Eimeria tenella.Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.Targeting the Lipid Metabolic Pathways for the Treatment of Malaria.Metabolic pathway analysis in trypanosomes and malaria parasitesA type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum.Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplastIn silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitorsApicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii.Parasite plastids: maintenance and functionsIdentifying apicoplast-targeting antimalarials using high-throughput compatible approachesMutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression.Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.Antimalarial drug discovery: efficacy models for compound screening.Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.Current advances in detection and treatment of babesiosisParasite plastids: approaching the endgame.The plastid-derived organelle of protozoan human parasites as a target of established and emerging drugs.Make it or take it: fatty acid metabolism of apicomplexan parasitesExpression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase.Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agentsLipidomic analysis of Toxoplasma gondii reveals unusual polar lipids.Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans
P2860
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P2860
Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Triclosan inhibits the growth ...... ibition of apicomplexan Fab I.
@ast
Triclosan inhibits the growth ...... ibition of apicomplexan Fab I.
@en
type
label
Triclosan inhibits the growth ...... ibition of apicomplexan Fab I.
@ast
Triclosan inhibits the growth ...... ibition of apicomplexan Fab I.
@en
prefLabel
Triclosan inhibits the growth ...... ibition of apicomplexan Fab I.
@ast
Triclosan inhibits the growth ...... ibition of apicomplexan Fab I.
@en
P2093
P50
P1476
Triclosan inhibits the growth ...... hibition of apicomplexan Fab I
@en
P2093
B U Samuel
M J Kirisits
W K Milhous
P304
P356
10.1016/S0020-7519(01)00111-4
P577
2001-02-01T00:00:00Z