Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection
about
Translational implications of the β-cell epigenome in diabetes mellitusGenome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivoIdentification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.GCN5 modulates osteogenic differentiation of periodontal ligament stem cells through DKK1 acetylation in inflammatory microenvironment.Trichostatin A affects the secretion pathways of beta and intestinal endocrine cells.A Thoroughly Validated Virtual Screening Strategy for Discovery of Novel HDAC3 Inhibitors.The role of butyrate, a histone deacetylase inhibitor in diabetes mellitus: experimental evidence for therapeutic intervention.Improving understanding of chromatin regulatory proteins and potential implications for drug discovery.HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent.Phenylbutyrate and β-cell function: contribution of histone deacetylases and ER stress inhibition.SOCS molecules: the growing players in macrophage polarization and function.Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes.The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay.Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice.The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells.HDAC Inhibition in Vascular Endothelial Cells Regulates the Expression of ncRNAs.MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage
P2860
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P2860
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection
description
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article published in the Proce ...... f the United States of America
@en
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2014
@ast
im Januar 2014 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel (gepubliceerd op 2014/01/21)
@nl
наукова стаття, опублікована в січні 2014
@uk
مقالة علمية: نشرت في 21-1-2014
@ar
name
Lysine deacetylase inhibition ...... gulation and β-cell protection
@ast
Lysine deacetylase inhibition ...... gulation and β-cell protection
@en
type
label
Lysine deacetylase inhibition ...... gulation and β-cell protection
@ast
Lysine deacetylase inhibition ...... gulation and β-cell protection
@en
prefLabel
Lysine deacetylase inhibition ...... gulation and β-cell protection
@ast
Lysine deacetylase inhibition ...... gulation and β-cell protection
@en
P2093
P2860
P50
P356
P1476
Lysine deacetylase inhibition ...... gulation and β-cell protection
@en
P2093
Conny Gysemans
Dan Ploug Christensen
Gianluca Fossati
Lars Groth Grunnet
Lykke Blaabjerg
Mattias Salling Dahllöf
Nikolai Birkbak
Paolo Mascagni
Reid A Aikin
Steven Paraskevas
P2860
P304
P356
10.1073/PNAS.1320850111
P407
P50
P577
2014-01-21T00:00:00Z