ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis.
about
Atypical retinoids: an expanding series of anti-leukemia and anti-cancer agents endowed with selective apoptotic activity.Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesRetinoid pathway and cancer therapeuticsCellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926.Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 OveractivationCancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid.Minireview: role of orphan nuclear receptors in cancer and potential as drug targetsThe synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma.The novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models.ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model.Nuclear receptor 4A (NR4A) family - orphans no more.p38αMAPK interacts with and inhibits RARα: suppression of the kinase enhances the therapeutic activity of retinoids in acute myeloid leukemia cells.Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA.Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models.Adamantyl-substituted retinoid-related molecules induce apoptosis in human acute myelogenous leukemia cells.Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response.Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cellsA novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosis.Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α.Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors
P2860
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P2860
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
ST1926, a novel and orally act ...... acellular calcium homeostasis.
@ast
ST1926, a novel and orally act ...... acellular calcium homeostasis.
@en
type
label
ST1926, a novel and orally act ...... acellular calcium homeostasis.
@ast
ST1926, a novel and orally act ...... acellular calcium homeostasis.
@en
prefLabel
ST1926, a novel and orally act ...... acellular calcium homeostasis.
@ast
ST1926, a novel and orally act ...... acellular calcium homeostasis.
@en
P2093
P1433
P1476
ST1926, a novel and orally act ...... acellular calcium homeostasis.
@en
P2093
Claudio Pisano
Daniele Simoni
Edoardo Parrella
Enrico Garattini
Fabiana Fosca Ferrara
Ilaria Chiarucci
Lucio Merlini
Luisa Diomede
Maurizio Gianni'
Mineko Terao
P304
P356
10.1182/BLOOD-2003-05-1577
P407
P577
2003-09-04T00:00:00Z