Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot.
about
Colicin biologyFollowing evolutionary paths to protein-protein interactions with high affinity and selectivityThe structural and energetic basis for high selectivity in a high-affinity protein-protein interactionA modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.Chemical and genetic wrappers for improved phage and RNA display.Analogous interactions in initiating complexes of the classical and lectin pathways of complementA force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.Structures of the Ultra-High-Affinity Protein-Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosaSequence and structural features of binding site residues in protein-protein complexes: comparison with protein-nucleic acid complexes.Blind prediction of interfacial water positions in CAPRIDiversification of β-Augmentation Interactions between CDI Toxin/Immunity ProteinsFlexibility and small pockets at protein-protein interfaces: New insights into druggability.Hot-spot residues at the E9/Im9 interface help binding via different mechanisms.E9-Im9 colicin DNase-immunity protein biomolecular association in water: a multiple-copy and accelerated molecular dynamics simulation studyNovel Immunity Proteins Associated with Colicin M-like Bacteriocins Exhibit Promiscuous Protection in Pseudomonas.Nuclease colicins and their immunity proteins.A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.Systematic mutation and thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions.Optimizing protein stability in vivoA "fuzzy"-logic language for encoding multiple physical traits in biomolecules.Using the concept of transient complex for affinity predictions in CAPRI rounds 20-27 and beyond.Conformational properties of the unfolded state of Im7 in nondenaturing conditionsInteractions of TolB with the translocation domain of colicin E9 require an extended TolB box.Rapid detection of colicin E9-induced DNA damage using Escherichia coli cells carrying SOS promoter-lux fusions.Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae.The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints.Inactivation of colicin Y by intramembrane helix-helix interaction with its immunity protein.Role of tyrosine hot-spot residues at the interface of colicin E9 and immunity protein 9: a comparative free energy simulation study.The Inclusion of Water Molecules in Residue Interaction Networks Identifies Additional Central ResiduesEvolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery
P2860
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P2860
Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Highly discriminating protein- ...... served binding energy hotspot.
@ast
Highly discriminating protein- ...... served binding energy hotspot.
@en
type
label
Highly discriminating protein- ...... served binding energy hotspot.
@ast
Highly discriminating protein- ...... served binding energy hotspot.
@en
prefLabel
Highly discriminating protein- ...... served binding energy hotspot.
@ast
Highly discriminating protein- ...... served binding energy hotspot.
@en
P2093
P50
P1476
Highly discriminating protein- ...... nserved binding energy hotspot
@en
P2093
Catriona Giffard
Colin Kleanthous
Geoffery R Moore
P304
P356
10.1016/J.JMB.2004.02.005
P407
P577
2004-03-01T00:00:00Z