A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.
about
Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptorMolecular targets for antiepileptic drug developmentStructural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune diseaseUse of venom peptides to probe ion channel structure and function.Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2Unique mechanism of the interaction between honey bee toxin TPNQ and rKir1.1 potassium channel explored by computational simulations: insights into the relative insensitivity of channel towards animal toxins.Tetraphenylporphyrin derivative specifically blocks members of the voltage-gated potassium channel subfamily Kv1.Molecular mechanism of δ-dendrotoxin-potassium channel recognition explored by docking and molecular dynamic simulations.A single conserved basic residue in the potassium channel filter region controls KCNQ1 insensitivity toward scorpion toxins.BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker.
P2860
Q24595276-C6F656E4-95AB-47E3-9DAF-097EAFE4E983Q24683346-5E16410A-0024-47B2-8CB1-29D7B4F072A1Q28280077-17081912-D582-4592-BE7E-49FD8B96C1C7Q33809867-FE99D7C6-35EB-47F4-91BD-BC5463F35D6FQ33938901-FEE6A575-A9E5-40B6-A9C6-AD3EA55F533FQ37001117-ACDC1EDB-E25D-4946-8D21-3FC405AD0228Q40201363-E8DBFAEE-64F7-4A9C-A8D2-701C55912DFCQ42684785-18D0CBD1-5CDA-4D35-B612-A654BD58DBB5Q47177522-3A324F9A-F4A4-4CDF-B4DA-74EDFB5A64D2Q47734366-4551B016-9379-44DB-A313-4B5F21FDECE4
P2860
A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
A variable residue in the pore ...... om sea anemones and scorpions.
@en
type
label
A variable residue in the pore ...... om sea anemones and scorpions.
@en
prefLabel
A variable residue in the pore ...... om sea anemones and scorpions.
@en
P2093
P2860
P356
P1476
A variable residue in the pore ...... om sea anemones and scorpions.
@en
P2093
André Ménez
Benoît Roux
Bernard Gilquin
Birgit T Priest
Maria L Garcia
Mats A L Eriksson
Sandrine Braud
Sylvaine Gasparini
Timothy D Bailey
P2860
P304
27093-27102
P356
10.1074/JBC.M413626200
P407
P577
2005-05-12T00:00:00Z