Parallel synthesis and antimalarial screening of a 4-aminoquinoline library. - Wikidata - wikimedia - TriplyDB

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

http://www.wikidata.org/entity/Q33202744

about

Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines.Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum Searching for new antimalarial therapeutics amongst known drugs.Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action Optimization of propafenone analogues as antimalarial leads Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.Reversed chloroquine molecules as a strategy to overcome resistance in malaria.Drug discovery for malaria: a very challenging and timely endeavor 4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity.Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones.4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy.4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum.Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines.Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum.A new route for the synthesis of highly substituted 4-aminoquinoline drug like molecules via aza hetero-Diels-Alder reaction.

P2860

Q30655275-3E9112D1-1CD3-4DC8-B508-B3731697F171 Q30980255-25FF92F1-DA28-4C08-BC9E-815C6AAAEF86 Q33224951-6886E267-8229-43D7-9E4A-51517A2D0247 Q33252500-3DB2B108-7725-4AA7-A181-BC24B043C315 Q33635667-7FD103B0-1676-4BD4-9812-0D042BAE7732 Q34694853-9BE97DF4-1D39-4E1D-9BDD-E61CD1067528 Q35523730-4DAACAB8-948D-4C5D-AFE9-638D22E47119 Q35951799-F0C75420-0553-44A7-885A-BFA2E2DF61F5 Q35969822-C7D9D769-26E8-4EA9-9E34-16FA6E1C069D Q36012422-63E41302-7B64-4FF0-9AD5-5FFE3A523ABB Q37432518-E3E49659-645F-42F9-9CF4-4302822665A0 Q39475539-0F38C054-00FB-41D7-8BDF-66FAD5B360F6 Q39627889-9B04B0BB-E892-4B2C-B137-3CC148329442 Q41772843-1E7C0B78-8891-47E9-AC08-0AD2E69BCFBF Q41775488-83D78FB9-160F-4F43-96A7-74D5F3826F61 Q41927067-4D177FDB-D13D-4203-9352-429EB78E3D80 Q41941261-CDBA6816-B5F0-4EE8-9AB3-AF55930C483D Q41944916-A4B29A6A-8EF4-4702-97F0-CF9CDBA2736F Q50961203-1F33CCE7-5C19-42B6-BD2B-F6259E3C0DF2

P2860

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

http://www.wikidata.org/entity/Q33202744

description

2004 nî lūn-bûn

@nan

2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

@ast

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

@en

type

label

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

@ast

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

@en

prefLabel

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

@ast

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

@en

P1433

Q33202744-98231A93-187F-427E-9092-7FC081A9EC3E

P1476

Q33202744-D0268899-D0F0-4F34-A8BA-EDCCB9F71C5E

P2093

Q33202744-74A3EFD9-085A-4C55-B7C9-E6C7D1B41FD3

Q33202744-7DE059B3-A820-4DF9-BB28-F53F19CD1ABA

Q33202744-D5467D0F-9E7B-4A81-9B6A-576406B00DC8

Q33202744-E2B2939E-654A-4C87-ACC6-9C4F5F866196

P2860

Q33202744-3F7B590B-3952-4506-A6A6-CB3C684A4D5A

Q33202744-4240EBCF-522D-4E04-9CEC-194E430ABFD4

Q33202744-4616068C-8174-4209-A8A6-321FC19FDAC1

Q33202744-46198E23-2453-44A3-8C50-DD0D7878E813

Q33202744-487F2987-6A28-42D7-AB50-D0CB9C2D06D3

Q33202744-49C6EEF9-9E71-4C6E-981D-9C41EF8835AA

Q33202744-714591C0-F84E-4399-8B05-D1FA6A6539D4

Q33202744-7DA556DA-2726-4D92-8734-A72F87D8B0BC

Q33202744-8B0582EB-D27B-4A3F-8DA6-18DCCA795D28

Q33202744-9117B13F-EF2F-4AA4-BCBB-0A4D12965279

P304

Q33202744-E0D38C6C-E98A-4DD5-8D87-0EB64012A909

P31

Q33202744-41029D37-CBD1-4273-B912-328454202220

P356

Q33202744-BFF6BBBD-D163-4665-B2A8-F6FF96141993

P433

Q33202744-20E49D2C-51AC-4744-8CC7-BE28FDB1C4BC

P478

Q33202744-58D0BE20-5977-4D64-8991-89F114165860

P577

Q33202744-59EA5D93-BDD2-4540-99D2-B6CCEA249B25

P5875

Q33202744-7467980C-91CF-487A-B03A-E4820DF0903F

P698

Q33202744-E6C25F58-98C8-4E44-BF38-14DE0BA7C83A

P921

Q33202744-D0A39B9C-7B7F-43FE-BD82-7B00BE23B031

P932

Q33202744-B0A4F1BA-4425-4ACE-8D28-73B0F441CDF7

P356

P1433

ACS Combinatorial Science

P1476

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.

@en

P2093

Joseph L DeRisi

http://www.w3.org/2001/XMLSchema#string

Nathan T Wilson

http://www.w3.org/2001/XMLSchema#string

Peter B Madrid

http://www.w3.org/2001/XMLSchema#string

R Kiplin Guy

http://www.w3.org/2001/XMLSchema#string

P2860

The economic and social burden of malaria

Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries.

A rapid, simple and sensitive flow cytometric system for detection of Plasmodium falciparum.

Quality control in combinatorial chemistry: determination of the quantity, purity, and quantitative purity of compounds in combinatorial libraries.

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1).

Plasmodium falciparum: rapid quantification of parasitemia in fixed malaria cultures by flow cytometry.

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

Optimisation of flow cytometric measurement of parasitaemia in plasmodium-infected mice.

Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro.

P304

437-442

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/CC0340473

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P577

2004-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8572446

http://www.w3.org/2001/XMLSchema#string

P698

15132606

http://www.w3.org/2001/XMLSchema#string

P921

P932

1467020

http://www.w3.org/2001/XMLSchema#string