4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
about
Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity.Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malariaPharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A MetalloproteaseA programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases.Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds.Antimalarial drugs and heme in detergent micelles: An NMR study.Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malariaSynthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter.Rational approach to an antiprion compound with a multiple mechanism of action.Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity.Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy.Deconstructing Quinoline-Class Antimalarials to Identify Fundamental Physicochemical Properties of Beta-Hematin Crystal Growth Inhibitors.Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum.Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.Malarial parasite pathogenesis and drug targets.Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas.7-Chloro-4-[(7-chloro-quinolin-4-yl)sulfan-yl]quinoline dihydrate.7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation.Synthesis of thieno[2,3-b]quinoline and selenopheno[2,3-b]quinoline derivatives via iodocyclization reaction and a DFT mechanistic study.Self-neutralizing oligonucleotides with enhanced cellular uptake.Design, Synthesis and Evaluation of Bifunctional Acridinine-Naphthalenediimide Redox-Active Conjugates as AntimalarialsDesign and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer
P2860
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P2860
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
4-N-, 4-S-, and 4-O-chloroquin ...... chloroquine resistant malaria.
@en
type
label
4-N-, 4-S-, and 4-O-chloroquin ...... chloroquine resistant malaria.
@en
prefLabel
4-N-, 4-S-, and 4-O-chloroquin ...... chloroquine resistant malaria.
@en
P2093
P2860
P356
P1476
4-N-, 4-S-, and 4-O-chloroquin ...... chloroquine resistant malaria.
@en
P2093
Angel C de Dios
Christian Wolf
Jayakumar K Natarajan
John N Alumasa
Kekeli A Ekoue-Kovi
Kimberly Yearick
Leah B Casabianca
Paul D Roepe
P2860
P304
P356
10.1021/JM701478A
P407
P577
2008-06-01T00:00:00Z