Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay.
about
Glutamate as a neurotransmitter in the healthy brainExon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.The use of Xenopus oocytes in drug screening.The importance of the excitatory amino acid transporter 3 (EAAT3)Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism.The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents.Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2.Excitatory amino acid transporters as potential drug targets.Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs.State-Dependent Allosteric Inhibition of the Human SLC13A5 Citrate Transporter by Hydroxysuccinic Acids, PF-06649298 and PF-06761281.Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2.Functional and morphological characterization of glutamate transporters in the rat locus coeruleus.Astrocyte Dysfunction Induced by Alcohol in Females but Not Males.Effect of ceftriaxone and topiramate treatments on naltrexone-precipitated morphine withdrawal and glutamate receptor desensitization in the rat locus coeruleus.Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1.Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102.
P2860
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P2860
Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Pharmacological characterizati ...... ased membrane potential assay.
@ast
Pharmacological characterizati ...... ased membrane potential assay.
@en
type
label
Pharmacological characterizati ...... ased membrane potential assay.
@ast
Pharmacological characterizati ...... ased membrane potential assay.
@en
prefLabel
Pharmacological characterizati ...... ased membrane potential assay.
@ast
Pharmacological characterizati ...... ased membrane potential assay.
@en
P1476
Pharmacological characterizati ...... ased membrane potential assay.
@en
P2093
Anders A Jensen
Hans Bräuner-Osborne
P304
P356
10.1016/J.BCP.2004.02.013
P407
P577
2004-06-01T00:00:00Z