A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. - Wikidata - wikimedia - TriplyDB

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

http://www.wikidata.org/entity/Q33202828

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Targeting cellular metabolism to improve cancer therapeutics Polyunsaturated fatty acid metabolism in prostate cancer Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker.Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication.Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers.Gerosuppressant metformin: less is more Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis.Fatty acid synthase as a potential therapeutic target in cancer.Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine.In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.Fatty acid synthase inhibitors: new directions for oncology.Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93.Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.Synthesis of novel beta-lactone inhibitors of fatty acid synthase.Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway.Revealing protein networks and gene-drug connectivity in cancer from direct information.Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model.Development of a Medium-Throughput Targeted LCMS Assay to Detect Endogenous Cellular Levels of Malonyl-CoA to Screen Fatty Acid Synthase Inhibitors.The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma.Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells.Fatty acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells.Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells.Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin.Visualizing inhibition of fatty acid synthase through mass spectrometric analysis of mitochondria from melanoma cells.Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis.Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway.Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis.High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.

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P2860

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

http://www.wikidata.org/entity/Q33202828

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@ast

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@en

type

label

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@ast

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@en

prefLabel

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@ast

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@en

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Journal of Biological Chemistry

P1476

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

@en

P2093

Cecille D Browne

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Fumiko Axelrod

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Jeffrey W Smith

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Lynn M Knowles

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P2860

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

Fatty acid synthesis: a potential selective target for antineoplastic therapy

Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer

Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro

Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro

Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control.

A method for application of samples to matrix-assisted laser desorption ionization time-of-flight targets that enhances peptide detection.

Cumulative effect of phosphorylation of pRB on regulation of E2F activity.

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30540-30545

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10.1074/JBC.M405061200

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29

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279

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2004-05-11T00:00:00Z

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