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Fatty acid synthesis: a potential selective target for antineoplastic therapy

Fatty acid synthesis: a potential selective target for antineoplastic therapy

http://www.wikidata.org/entity/Q24561903

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Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells Human fatty acid synthase: properties and molecular cloning Links between metabolism and cancer Polyunsaturated fatty acid metabolism in prostate cancer Brick by brick: metabolism and tumor cell growth MYC and metabolism on the path to cancer Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer Tumor suppressor p53 and its mutants in cancer metabolism Lipid biology of breast cancer Hypothalamic malonyl-CoA and the control of food intake Inhibition of the fungal fatty acid synthase type I multienzyme complex The crystal structure of a mammalian fatty acid synthase A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis Conformational flexibility of metazoan fatty acid synthase enables catalysis Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity.Direct visualization of de novo lipogenesis in single living cells Decrease and gain of gene expression are equally discriminatory markers for prostate carcinoma: a gene expression analysis on total and microdissected prostate tissue.A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.Tumor macroenvironment and metabolism.Pathogenesis of ovarian cancer: clues from selected overexpressed genes.Tafazzin protein expression is associated with tumorigenesis and radiation response in rectal cancer: a study of Swedish clinical trial on preoperative radiotherapy Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity Metabolic targeting of malignant tumors: small-molecule inhibitors of bioenergetic flux.Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells.Metabolic genes in cancer: their roles in tumor progression and clinical implications Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells.Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas Effects of lovastatin on breast cancer cells: a proteo-metabonomic study.Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker.

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P2860

Fatty acid synthesis: a potential selective target for antineoplastic therapy

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1994 nî lūn-bûn

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1994 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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1994 թվականի հուլիսին հրատարակված գիտական հոդված

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1994年の論文

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1994年学术文章

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

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Proceedings of the National Academy of Sciences of the United States of America

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

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F D Wood

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F P Kuhajda

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P2860

Fatty acid synthase, a proficient multifunctional enzyme

In vitro inhibition of HIV-1 proteinase by cerulenin

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis

Identification of clinical isolates of gram-negative nonfermentative bacteria by an automated cellular fatty acid identification system.

Expression of haptoglobin-related protein and its potential role as a tumor antigen

Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.

Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein.

Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA

Current status of adjuvant therapy of early breast cancer.

The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis.

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